Evidence map›Paper›PMID 34992965›Full record

ArticleNeurology. Clinical practice2021

Prevalence and Cumulative Incidence of Caregiver-Reported Aggression in Advanced Parkinson Disease and Related Disorders.

Zachary A Macchi, Janis Miyasaki, Maya Katz, Nicholas Galifianakis, Stefan Sillau, Benzi M Kluger

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02533921 (Does Outpatient Palliative Care Improve Patient-centered Outcomes in Parkinson's Disease?), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02533921 nacompletednot on this map

Does Outpatient Palliative Care Improve Patient-centered Outcomes in Parkinson's Disease?

TypeinterventionalSponsorUniversity of Colorado, DenverRan2015 to 2019Enrolled210ConditionsParkinson's DiseaseArmsInterdisciplinary outpatient palliative care, Standard of Care
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Physical Violence and Aggression in Parkinson's Disease: A Systematic Review.Journal of the Academy of Consultation-Liaison Psychiatry
    Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Zachary A MacchiDepartment of Neurology (ZAM, SS), and Department of Internal Medicine (ZAM), University of Colorado Anschutz, Aurora; Division of Neurology (JM), Department of Medicine, University of Alberta, Edmonton, Canada; Department of Neurology (MK, NG), University of California San Francisco Medical Center; and Departments of Neurology and Medicine (BMK), University of Rochester Medical Center, NY.ORCID 0000-0001-8900-9500
Janis MiyasakiDepartment of Neurology (ZAM, SS), and Department of Internal Medicine (ZAM), University of Colorado Anschutz, Aurora; Division of Neurology (JM), Department of Medicine, University of Alberta, Edmonton, Canada; Department of Neurology (MK, NG), University of California San Francisco Medical Center; and Departments of Neurology and Medicine (BMK), University of Rochester Medical Center, NY.ORCID 0000-0002-6372-6007
Maya KatzDepartment of Neurology (ZAM, SS), and Department of Internal Medicine (ZAM), University of Colorado Anschutz, Aurora; Division of Neurology (JM), Department of Medicine, University of Alberta, Edmonton, Canada; Department of Neurology (MK, NG), University of California San Francisco Medical Center; and Departments of Neurology and Medicine (BMK), University of Rochester Medical Center, NY.
Nicholas GalifianakisDepartment of Neurology (ZAM, SS), and Department of Internal Medicine (ZAM), University of Colorado Anschutz, Aurora; Division of Neurology (JM), Department of Medicine, University of Alberta, Edmonton, Canada; Department of Neurology (MK, NG), University of California San Francisco Medical Center; and Departments of Neurology and Medicine (BMK), University of Rochester Medical Center, NY.
Stefan SillauDepartment of Neurology (ZAM, SS), and Department of Internal Medicine (ZAM), University of Colorado Anschutz, Aurora; Division of Neurology (JM), Department of Medicine, University of Alberta, Edmonton, Canada; Department of Neurology (MK, NG), University of California San Francisco Medical Center; and Departments of Neurology and Medicine (BMK), University of Rochester Medical Center, NY.
Benzi M KlugerDepartment of Neurology (ZAM, SS), and Department of Internal Medicine (ZAM), University of Colorado Anschutz, Aurora; Division of Neurology (JM), Department of Medicine, University of Alberta, Edmonton, Canada; Department of Neurology (MK, NG), University of California San Francisco Medical Center; and Departments of Neurology and Medicine (BMK), University of Rochester Medical Center, NY.ORCID 0000-0002-6259-329X
University of Alberta · CA

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
More than a Movement Disorder: Applying Palliative Care to Parkinson's Disease and Lewy Body DementiasR01NR016037 · NINR · UNIVERSITY OF ROCHESTER · PI KLUGER, BENZI M · 2016 to 2025
$6.5M
Multidisciplinary Research Training in Palliative CareT32AG044296 · NIA · UNIVERSITY OF COLORADO DENVER · PI STACY M FISCHER, JEAN S KUTNER · 2014 to 2026
$3.3M
Advancing Palliative Care for Older Adults Affected by Neurodegenerative Disease: Parkinsons disease, Alzheimers disease and Related DementiasK02AG062745 · NIA · UNIVERSITY OF ROCHESTER · PI KLUGER, BENZI M · 2020 to 2024
$711k
NCRR NIH HHS UL1 RR025780NIA NIH HHS K02 AG062745NIA NIH HHS T32 AG044296NINR NIH HHS R01 NR016037
6 · The paper itself

Abstract

objectiveTo estimate the point prevalence and cumulative incidence of caregiver-reported aggressive behaviors among people living with advanced Parkinson disease and related disorders (PDRDs) and secondarily examine variables associated with aggression.

methodsCaregivers from a clinical trial of outpatient palliative care for PDRD were surveyed about patient aggression at baseline and every 3 months over 12 months. Baseline responses were used for point prevalence. Cumulative incidence was calculated using responses from caregivers with no reported baseline aggression and available data at all other time points. Measures of disease severity, quality of life, mood, and caregiver burden were included in correlation and relative risk models, adjusting for age, sex, and diagnosis.

resultsOf 170 caregivers, 31 (18.2%) reported physical aggression, and 18 (10.6%) reported sexual aggression. Twelve-month cumulative incidence for physical and sexual aggression was 21.1% (23/109) and 16.0% (19/119), respectively. Physical aggression cumulative incidence was associated with patient depression (

conclusionThere was a high prevalence and incidence of aggression in our PDRD cohort. This is an understudied issue in PDRD, and our findings highlight the need for increased awareness among neurologists. Providers should consider assessing for aggression when discussing neuropsychiatric symptoms or screening for caregiver burden. Future research should examine the relationship between aggression and patient and caregiver health outcomes. TRIAL REGISTRATION INFORMATION: Clinical trial registration number: NCT02533921.

Identifiers

PMID34992965
PMCPMC8723973
OpenAlexW3175284424

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.