Evidence map›Paper›PMID 34992853›Full record

ArticleTranslational neuroscience2021

Neuroprotective effects of the

Pacôme Kouadio N'Go, Omar Touhami Ahmed Ahami, Aboubaker El Hessni, Fatima-Zahra Azzaoui, Youssef Aboussaleh, Antoine Némé Tako

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Pacôme Kouadio N'GoPeleforo GON COULIBALY University, Training and Research Unit of Biological Sciences, Department of Animal Biology, PO Box 1328, Korhogo, Ivory Coast.
Omar Touhami Ahmed AhamiClinical and Cognitive Neurosciences Group, Biology and Health Lab, Ibn Tofail University, PO Box 133, Kenitra, Morocco.
Aboubaker El HessniGenetic, Neuroendocrinology and Biotechnology Team, Biology and Health Lab, Department of Biology, Ibn Tofail University, PO Box 133, Kenitra, Morocco.
Fatima-Zahra AzzaouiClinical and Cognitive Neurosciences Group, Biology and Health Lab, Ibn Tofail University, PO Box 133, Kenitra, Morocco.
Youssef AboussalehClinical and Cognitive Neurosciences Group, Biology and Health Lab, Ibn Tofail University, PO Box 133, Kenitra, Morocco.
Antoine Némé TakoNeurosciences Team, Biology and Health Lab, Department of Biosciences, Felix Houphouet Boigny University, 01 BPV 34 Abidjan 01, Abidjan, Ivory Coast.
Université Ibn-Tofail · MAUniversité Félix Houphouët-Boigny · CI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlzheimer's disease (AD) is a threatening disease for African populations in the upcoming years because of the increase in their expectancy of life. Here, we investigated whether natural products from METHODOLOGY: Adult male Wistar rats were either microinjected with 1% ammonia as a vehicle (10 µL) or aggregated Aβ

resultsAβ rats exhibited significant deficits of recognition memory and spatial learning. This was associated with an increase of microglia Iba 1 immunoreactivity as well as nitric oxide (NO), malondialdehyde and superoxide dismutase levels but not to the thiol content in the hippocampus, prefrontal cortex and septum of AD-like rats. The

conclusionThese findings are preliminary and should be strengthened by more pharmacological studies of bioactive compounds of

Indexed as

Alzheimer’s diseaseChrysophyllum perpulchrummicrogliaoxidative stress markersrecognition memoryspatial learning

Identifiers

PMID34992853
PMCPMC8678622
OpenAlexW4205205524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.