Evidence map›Paper›PMID 34992852›Full record

ReviewTranslational neuroscience2021

Benefits of vitamin D supplementation to attenuate TBI secondary injury?

Kiana Saadatmand, Saba Khan, Quaratulain Hassan, Raymond Hautamaki, Rani Ashouri, Josh Lua, Sylvain Doré

Open access · goldAbstract readReview
In one paragraph

Review in Translational neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Vitamin D status and clinical implications in the adult population of Malaysia: a position paper by the Malaysian Vitamin D Special Interest Group.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kiana SaadatmandDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, United States of America.
Saba KhanDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, United States of America.
Quaratulain HassanDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, United States of America.
Raymond HautamakiDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, United States of America.
Rani AshouriDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, United States of America.
Josh LuaDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, United States of America.
Sylvain DoréDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, United States of America.
University of Florida · USFlorida College · US

Funding

Regulation and Implication of Hemoglobin Clearance in Subarachnoid Hemorrhagic PatientsR21NS095166 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2016 to 2017
$426k
CO therapeutic role and potential mechanism in TBIR21NS103036 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2018 to 2019
$419k
Potential stroke therapeutic efficacy of FumET-CORM through the Nrf2 pathwayR21NS110008 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2019 to 2019
$419k
Testing brain penetrant iron chelators and investigating putative clearance pathway in ICHR56NS116076 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2020 to 2020
$381k
NINDS NIH HHS R21 NS095166NINDS NIH HHS R21 NS103036NINDS NIH HHS R21 NS110008NINDS NIH HHS R56 NS116076
6 · The paper itself

Abstract

Vitamin D supplementation has been shown to improve outcomes for patients suffering from a variety of illnesses such as stroke and cancer. Vitamin D deficiencies have been associated with longer hospital stays, greater severity of symptoms, and death in some complex cases. Due to vitamin D's burgeoning role in improving patient outcomes, a new sector of research is focusing on the lesser-known implications of vitamin D on health. Traumatic brain injury (TBI) affects approximately 69 million people worldwide per year. Here, we summarize the current scientific understanding of vitamin D dynamics with TBI to elucidate a potential way to lessen the cascade of secondary damage after an initial insult, with the goal of improving overall patient outcomes. Because vitamin D supplementation has been correlated with better outcomes in other pathologies involving immune and inflammatory molecules, it is important to study the potential effect of vitamin D deficiency (VDD) and supplementation on TBI outcomes. Research on vitamin D supplementation in TBI remains in the preliminary stages. There is still much to learn about vitamin D deficiency, dosage, variants of supplementary forms, mechanisms, and its role in TBI.

Indexed as

calcidiolcalcitriolconcussiontraumatic brain injuryvitamin D receptor

Identifiers

PMID34992852
PMCPMC8678475
OpenAlexW4205657204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.