Evidence map›Paper›PMID 34992590›Full record

ReviewFrontiers in microbiology2021

Host Immune Responses to

Britt Nibbering, Dale N Gerding, Ed J Kuijper, Romy D Zwittink, Wiep Klaas Smits

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06030245 (Clostridioides Difficile Infection), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06030245 recruitingnot on this mapstarted 2023, after this paper: background citation

Clostridioides Difficile Infection: Prospective Cohort Analyzing CLInic Evolution and Bacterial Clearance

TypeobservationalSponsorFondation Hôpital Saint-JosephRan2023 to 2027Enrolled100ConditionsClostridium Difficile Infections
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Colonic epithelial regeneration shapes susceptibility tobioRxiv : the preprint server for biology · 2026
    Article
  5. Observational
  6. Article
  7. The critical role ofApplied and environmental microbiology · 2026
    Article
  8. Gut microbes · 2025
    Article
  9. Review
  10. Review
  11. A Mouse Model of MildMicroorganisms · 2024
    Article
  12. Article
  13. Clinical microbiology reviews · 2024
    Review
  14. A new lexicon in the age of microbiome research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  15. Article
  16. Article
  17. Reviewing theMicroorganisms · 2024
    Review
  18. Pathogens (Basel, Switzerland) · 2024
    Review
  19. Global insights into the genome dynamics ofFrontiers in cellular and infection microbiology · 2024
    Article
  20. Immunization Strategies Against Clostridioides difficile.Advances in experimental medicine and biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Britt NibberingCenter for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, Netherlands.
Dale N GerdingDepartment of Veterans Affairs, Research Service, Edward Hines Jr. VA Hospital, Hines, IL, United States.
Ed J KuijperCenter for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, Netherlands.
Romy D ZwittinkCenter for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, Netherlands.
Wiep Klaas SmitsCenter for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, Netherlands.
Leiden University Medical Center · NLEdward Hines, Jr. VA Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Clostridioides difficileimmune responsenon-toxigenic C. difficilenon-toxin proteinsNTCDtoxins

Identifiers

PMID34992590
PMCPMC8724541
OpenAlexW4200067418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.