Evidence map›Paper›PMID 34992474›Full record

ArticleInternational medical case reports journal2021

Delayed Epithelial Healing with Corneal Edema and Haze After Photorefractive Keratectomy Using Intraoperative Mitomycin C.

Majid Moshirfar, William B West, Dallin C Milner, Shannon E McCabe, Yasmyne C Ronquillo, Phillip C Hoopes

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International medical case reports journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06854393 (Lacripep, a Novel Investigational Agent, for Corneal Wound Healing and Ocular Surface Homeostasis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06854393 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Lacripep, a Novel Investigational Agent, for Corneal Wound Healing and Ocular Surface Homeostasis

TypeinterventionalSponsorHenry M. Jackson Foundation for the Advancement of Military MedicineRan2025 to 2027Enrolled88ConditionsCorneal Epithelial Wound HealingArms0.00025% Lacripep ophthalmic solution and Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Majid MoshirfarHoopes Vision Research Center, Hoopes Vision, Draper, UT, 84020, USA.ORCID 0000-0003-1024-6250
William B WestUniversity of Utah School of Medicine, Salt Lake City, UT, 84132, USA.
Dallin C MilnerUniversity of Colorado School of Medicine, Aurora, CO, 80045, USA.
Shannon E McCabeHoopes Vision Research Center, Hoopes Vision, Draper, UT, 84020, USA.ORCID 0000-0002-6339-3628
Yasmyne C RonquilloHoopes Vision Research Center, Hoopes Vision, Draper, UT, 84020, USA.ORCID 0000-0002-8852-4380
Phillip C HoopesHoopes Vision Research Center, Hoopes Vision, Draper, UT, 84020, USA.ORCID 0000-0002-2567-8331
Hoopes Vision · USUniversity of Utah · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an unusual presentation of presumed mitomycin C toxicity with possible subsequent hypersensitization to other medication toxicities. A 50-year-old female presented three months after photorefractive keratectomy with intraoperative mitomycin C for the management of persistent epithelial defects, corneal haze, and edema. She was found to have used an expansive and rapidly changing medical regimen which may have caused additional toxicity. These medications included besifloxacin, bromfenac, and ketotifen. Additives such as benzalkonium chloride and DuraSite

Indexed as

corneal toxicityhypersensitivitymedication toxicitymitomycin corneal toxicityphotorefractive keratectomypolypharmacysurface ablation

Identifiers

PMID34992474
PMCPMC8714007
OpenAlexW4200069406

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.