ArticleInternational journal of general medicine2021
Impaired Interhemispheric Synchrony in Bronchial Asthma.
Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Unknotting the nexus of asthma and neuroinflammation: from brain network alterations to therapeutic implications.Journal of neuroinflammation · 2026Review
- Functional connectivity alterations in the thalamus among patients with bronchial asthma.Frontiers in neurology · 2024Article
- Exploration of static functional connectivity and dynamic functional connectivity alterations in the primary visual cortex among patients with high myopiaFrontiers in neuroscience · 2023Article
- Machine learning analysis reveals aberrant dynamic changes in amplitude of low-frequency fluctuations among patients with retinal detachment.Frontiers in neuroscience · 2023Article
- Investigation of altered spontaneous brain activity in patients with bronchial asthma using the percent amplitude of fluctuation method: a resting-state functional MRI study.Frontiers in human neuroscience · 2023Article
- Asthma's effect on brain connectivity and cognitive decline.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeConverging evidence demonstrated that bronchial asthma (BA) individuals with hypoxia were associated with functional and morphological reorganization in the brain. However, the alterations of the interhemispheric functional connectivity in BA individuals remain unknown. The purpose of this study was to assess the interhemispheric functional connectivity changes in individuals with hypoxia due to middle-aged BA using voxel-mirrored homotopic connectivity (VMHC) methods.
methodsIn total, 31 BA individuals and 30 healthy controls (HCs) closely matched in age, sex, and education underwent resting-state magnetic resonance imaging (MRI) scans. VMHC analysis was performed to investigate differences in interhemispheric functional connectivity between the two groups. Then, a seed-based resting-state functional connectivity (rsFC) analysis was conducted to further reveal the abnormal functional connectivity between the altered VMHC regions and the whole brain.
resultsCompared with HCs, BA individuals had significantly lower VMHC values in the bilateral basal ganglia/thalamus/insula, cuneus/calcarine/lingual gyrus, precentral and postcentral gyrus. [voxel level P < 0.01, Gaussian random field (GRF) correction, cluster level P < 0.05]. Taking VMHC altered brain areas as seed points, the rsFC values of left insula/supramarginal/postcentral gyrus (PostCG)/inferior parietal lobule (IPL) brain areas in BA were increased.
conclusionThe abnormal resting-state functional connectivity of middle-aged BA is altered in specific brain regions related to the basal ganglia network, visual network, and sensorimotor network, which may be related to the neuropathogenesis of asthma patients. Furthermore, these VMHC and FC values may be important clinical indicators for the diagnosis and treatment of asthma patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.