Evidence map›Paper›PMID 34992416›Full record

ArticleJournal of inflammation research2021

Acute Exposure to the Food-Borne Pathogen

Anthony M Mancinelli, Jonathan M Vichich, Alexandra D Zinnen, Anna Marie Hugon, Viktoriya Bondarenko, Jeanette M Metzger, Heather A Simmons, Thaddeus G Golos, Marina E Emborg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anthony M MancinelliWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Jonathan M VichichWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Alexandra D ZinnenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Anna Marie HugonDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Viktoriya BondarenkoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Jeanette M MetzgerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Thaddeus G GolosWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Marina E EmborgWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-9351-6641
University of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SAGER, MARK · 2009 to 2018
$16.2M
The Maternal-Fetal Interface in Listeria-Induced Pregnancy LossR01AI107157 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GOLOS, THADDEUS G · 2014 to 2017
$1.6M
NIAID NIH HHS R01 AI107157NIA NIH HHS P50 AG033514NIH HHS P51 OD011106
6 · The paper itself

Abstract

introductionGastrointestinal (GI) inflammation elicited by environmental factors is proposed to trigger Parkinson's disease (PD) by stimulating accumulation of pathological α-synuclein (α-syn) in the enteric nervous system (ENS), which then propagates to the central nervous system via the vagus nerve. The goal of this study was to model, in nonhuman primates, an acute exposure to a common food-borne pathogen in order to assess whether the related acute GI inflammation could initiate persistent α-syn pathology in the ENS, ultimately leading to PD.

methodsAdult female cynomolgus macaques were inoculated by oral gavage with 1×10

resultsLM inoculation of healthy adult cynomolgus macaques induced minimal to mild clinical signs of infection; LM shedding in feces was not seen in any of the animals nor was bacteremia detected. Colitis varied from none to moderate in LM-treated subjects and none to minimal in mock-treated subjects. Expression of inflammatory markers (HLA-DR, CD3, CD20), oxidative stress (8-OHDG), α-syn, and phosphorylated-α-syn in the enteric ganglia was not significantly different between treatment groups. DISCUSSION: Our results demonstrate that cynomolgus macaques orally inoculated with LM present with a clinical response that resembles human LM exposure. They also suggest that acute exposure to food-borne pathogens is not sufficient to induce significant and persistent α-syn changes in healthy adult female subjects. Based on the results of this limited experimental setting, we propose that, if LM has a role in PD pathology, other underlying factors or conditions, such as male sex, inflammatory bowel disease, exposure to toxins, dysbiosis, and/or aging, are needed to be present.

Indexed as

alpha synucleinenteric nervous systeminflammationlisterianonhuman primateParkinson’s disease

Identifiers

PMID34992416
PMCPMC8710837
OpenAlexW4200423925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.