ReviewClinical, cosmetic and investigational dermatology2021
An Overview of Soft Tissue Fillers for Cosmetic Dermatology: From Filling to Regenerative Medicine.
Review in Clinical, cosmetic and investigational dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Autologous Fat Grafting Versus Facial Fillers in Facial Cosmesis: A Systematic review and Meta-analysis.Aesthetic plastic surgery · 2026Pooled it
- Aesthetic lip filler augmentation is not free of adverse reactions: lack of evidence-based practice from a systematic review.Frontiers in oral health · 2024Pooled it
- Assessment of Hyaluronic Acid Filler in Gluteal Augmentation and Contouring: A 1-Year Prospective Study.Journal of cosmetic dermatology · 2025Trial
- Increasing Facial Attractiveness by Lateralizing the Auricle-Analyzing the Pan-Facial Effects of the Postauricular Injection Technique in Chinese Patient Populations.Aesthetic plastic surgery · 2025Trial
- Safety and Efficacy of a "High and Low Molecular Weight Hyaluronic Acid Hybrid Complex" Injection for Face Rejuvenation.Journal of cosmetic dermatology · 2025Trial
- Pipeline of Devices and Aesthetics: What Is Left?The Journal of clinical and aesthetic dermatology · 2026Article
- Rheological and Physicochemical Properties of Hyaluronic Acid Fillers for Body Contouring: Clinical Implications and Anatomical Considerations.Journal of cosmetic dermatology · 2026Article
- Enhanced Facial Rejuvenation: Biostimulatory Effects of Hylan Gel Dermal Filler DX on Collagen Synthesis and Tissue Regeneration.Aesthetic plastic surgery · 2026Article
- Complications of Dermal Injectables-A Retrospective Study.Journal of cosmetic dermatology · 2026Article
- Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Recent Advances in Injectable Hydrogels for Biomedical and Aesthetic Applications: Focus on Rheological Characteristics.Gels (Basel, Switzerland) · 2025Review
- Efficacy and Safety of a Stabilized Composition of 26 mg/mL of High Molecular Weight Hyaluronic Acid for Aesthetic Applications.Journal of clinical medicine · 2025Article
- Are We Overlooking Harms of BDDE-Cross-Linked Dermal Fillers? A Scoping Review.Aesthetic plastic surgery · 2024Article
- Manufacturing Process of Hyaluronic Acid Dermal Fillers.Polymers · 2024Review
- Treating energy-based devices and hyaluronic acid filler injection together?Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine?International journal of molecular sciences · 2024Review
- Subcutaneous Application of a Gelatin/Hyaluronic Acid Hydrogel Induces the Production of Skin Extracellular Matrix.Polymers · 2024Article
- A Covalently Cross-Linked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Potential Filler for Soft Tissue Augmentation.Gels (Basel, Switzerland) · 2024Article
- Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation.Clinical, cosmetic and investigational dermatology · 2024Article
- Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review.World journal of diabetes · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA)-based injectable filling agents are at the forefront of the current demand for noninvasive dermatological procedures for the correction of age-related soft tissue defects. The present review aims to summarize currently available HA-based products and critically appraise their differences in rheological nature and clinical application. Linear HA (LHA) gels may be supplemented with amino acids, lipoic acid, vitamins, nucleosides, or minerals for synergistic antiaging and antioxidant benefits (polycomponent LHA). HA hydrogels can be generated via chemical or physical crosslinking, which increases their elasticity and decreases viscosity. The performance of crosslinked fillers depends on HA concentration, degree of crosslinking, elastic modulus, cohesivity, and type of crosslinking agent employed. PEG-crosslinked LHA displays improved elasticity and resistance to degradation, and lower swelling rates as compared to BDDE-crosslinked LHA. Physical crosslinking stabilizes HA hydrogels without employing exogenous chemical compounds or altering hyaluronans' natural molecular structure. Thermally stabilized hybrid cooperative HA complexes (HCC) are a formulation of high- and low-molecular-weight (H-HA and L-HA) hyaluronans, achieving high HA concentration, low viscosity with optimal tissue diffusion, and a duration comparable to weakly cross-linked gel. Our critical analysis evidences the importance of understanding different fillers' properties to assist physicians in selecting the most appropriate filler for specific uses and for predictable and sustainable results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.