Evidence map›Paper›PMID 34992390›Full record

ArticleInfection and drug resistance2021

Impact of Carbapenem Heteroresistance Among Multidrug-Resistant ESBL/AmpC-Producing

Yilin Xiong, Yuqiao Han, Zinan Zhao, Wenting Gao, Yong Ma, Shiyu Jiang, Mengyao Wang, Qingqing Zhang, Yun Zhou, Yang Chen

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Tandem amplification of theMicrobiology spectrum · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Traditional marketed meats as a reservoir of multidrug-resistant Escherichia coli.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  9. Article
  10. Review
  11. CombatingFrontiers in cellular and infection microbiology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Relationships between Efflux Pumps and Emergence of Heteroresistance: A Comprehensive Study on the Current Findings.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yilin Xiong *Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.
Yuqiao Han *Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.ORCID 0000-0002-8187-8151
Zinan Zhao *Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.
Wenting GaoInstitute of Genome Engineered Animal Models for Human Disease, Dalian Medical University, Dalian, People's Republic of China.
Yong MaInstitute of Genome Engineered Animal Models for Human Disease, Dalian Medical University, Dalian, People's Republic of China.
Shiyu JiangDepartment of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.ORCID 0000-0003-0348-412X
Mengyao WangDepartment of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.
Qingqing ZhangLaboratory of Pathogenic Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.
Yun ZhouDepartment of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Yang ChenDepartment of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.ORCID 0000-0001-9023-1010
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAntibiotic resistance is a growing health crisis that is further complicated by treatment failures caused by bacteria that exhibit heterogeneous susceptibility to antibiotics. The aim of this study was to describe imipenem (IPM)-heteroresistant strains among multidrug-resistant (MDR) ESBL/AmpC-producing MATERIALS AND

methodsAntimicrobial susceptibility of

resultsIn total, 37 MDR ESBL/AmpC-producing clinical isolates of

conclusionCarbapenem-heteroresistant strains were present among the MDR

Indexed as

Enterobacteriaceaeheterogeneous susceptibilityimipenemin vivoOmpK porintreatment failure

Identifiers

PMID34992390
PMCPMC8711563
OpenAlexW4200386557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.