ArticleInternational journal of nanomedicine2021
Anti-Acid Biomimetic Dentine Remineralization Using Inorganic Silica Stabilized Nanoparticles Distributed Electronspun Nanofibrous Mats.
Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Nanomaterials Modulating the Fate of Dental-Derived Mesenchymal Stem Cells Involved in Oral Tissue Reconstruction: A Systematic Review.International journal of nanomedicine · 2023Pooled it
- Mussel-inspired silica, strontium, and fluoride-doped hydroxyapatite/BMP-2 composite coating: a new strategy to enhance the bioactivity of zirconia implants.RSC advances · 2026Article
- Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence.The Japanese dental science review · 2025Review
- From medical strategy to foodborne prophylactic strategy: Stabilizing dental collagen with aloin.Food science & nutrition · 2024Article
- Advanced materials and technologies for oral diseases.Science and technology of advanced materials · 2023Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo manage the sharp pain of dentine hypersensitivity, various materials are utilized to conduct dentine remineralization. However, many prior materials are limited with their single function and complicated operations. In this study, silica and calcium (strontium) carbonates mineralized nano cellulose fibrous (Si/Ca(Sr)-NCF) mat with the ability to release acid resistant and biomimetic mineralizational silica/calcium (strontium) carbonate co-precipitation nanoparticles (Si/Ca(Sr) NPs) were fabricated. The dentine occluding effects, antibacterial activity and cytocompatibility of the Si/Ca(Sr)-NCF mats were evaluated.
methodsThe Si/Ca(Sr)-NCF mats were fabricated by dipping the electrospun nano cellulose fiber (NCF) into silica and calcium (strontium) carbonate liquid. Physicochemical characterizations and ion release were confirmed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), ion release assays and transmission electron microscopy (TEM). Sixty dentine discs were randomly divided into five groups: 1, blank NCF; 2, Si/Ca(Sr 0)-NCF; 3, Si/Ca(Sr 0.01)-NCF; 4, Si/Ca(Sr 0.05)-NCF; 5, Si/Ca(Sr 0.1)-NCF. Dentine discs were mineralized by the mats and observed with SEM immediately, after acid challenge and remineralized in artificial saliva. The releasing liquid was investigated by TEM and type I collagen model. Then, antibacterial property and cytocompatibility were evaluated.
resultsSEM and TEM results confirmed that the experiment mats continuously released amorphous Si/Ca(Sr) NPs and consequently realized anti-acid dentine biomimetic remineralization. Homogeneous surface coverage and collagen intrafibrillar mineralization in strontium adding groups illustrated the mineralization effect was not only by in site precipitation, but also collagen heterogeneous nucleation. Additionally, acceptable antibacterial and cytocompatibility properties were illustrated in low and middle Sr
conclusionIn vitro studies on human dentine discs and type I collagen demonstrated that Si/Ca(Sr)-NCF system was a multifunction system inducing anti-acid, biomimetic, antibacterial and cytocompatible dentine remineralization. This multifunction mat would be a promising DH treatment candidate for complicated exposed dentine surfaces.
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