Evidence map›Paper›PMID 34992331›Full record

ArticleIndustrial & engineering chemistry research2021

Mathematical Modeling of the Gut-Bone Axis and Implications of Butyrate Treatment on Osteoimmunology.

Mohammad Aminul Islam, Carley V Cook, Brenda J Smith, Ashlee N Ford Versypt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Industrial & engineering chemistry research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Climate change and its effects on body size and shape: the role of endocrine mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Mathematical modeling of the effects of Wnt-10b on bone metabolism.AIChE journal. American Institute of Chemical Engineers · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohammad Aminul IslamDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States; School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Carley V CookDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States; School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Brenda J SmithDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, United States.ORCID 0000-0002-7296-8534
Ashlee N Ford VersyptDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States; School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, United States; Institute for Computational and Data Sciences, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.ORCID 0000-0001-9059-5703
Oklahoma State University · US

Funding

Quantitative Systems Biomedicine and Pharmacology for Multiscale Tissue DamageR35GM133763 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Ashlee Nicole Ford Versypt · 2019 to 2026
$2.7M
NIGMS NIH HHS R35 GM133763
6 · The paper itself

Abstract

Butyrate, a short-chain fatty acid produced by the gut microbiota, has pivotal roles in the regulation of the immune system. Recent studies have revealed that butyrate increases the differentiation of peripheral regulatory T cells in the gut-bone axis and promotes osteoblasts' bone forming activity. However, the mechanism of the therapeutic benefit of butyrate in bone remodeling remains incompletely understood. Here, we develop a multicompartment mathematical model to quantitatively predict the contribution of butyrate on the expansion of regulatory T cells in the gut, blood, and bone compartments. We investigate the interplay between regulatory T cell-derived TGF-

Identifiers

PMID34992331
PMCPMC8730472
OpenAlexW3217504250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.