Evidence map›Paper›PMID 34992275›Full record

ArticleCellular & molecular immunology2022

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination.

Yeonsu Kim, Xiaoyan Zheng, Kathrin Eschke, M Zeeshan Chaudhry, Federico Bertoglio, Adriana Tomić, Astrid Krmpotić, Markus Hoffmann, Yotam Bar-On, Julia Boehme and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Quest for Immunity: Exploring Human Herpesviruses as Vaccine Vectors.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Review
  13. Article
  14. COVID-19 mRNA vaccines: Platforms and current developments.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 4 countries.

Yeonsu Kim *Department of Viral Immunology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Xiaoyan Zheng *Department of Viral Immunology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Kathrin Eschke *Department of Viral Immunology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
M Zeeshan Chaudhry *Department of Viral Immunology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.ORCID http://orcid.org/0000-0002-1372-4257
Federico BertoglioDepartment of Biotechnology, Institut für Biochemie, Biotechnologie und Bioinformatik, Technischen Universität Braunschweig, Braunschweig, Germany.ORCID http://orcid.org/0000-0001-6477-1785
Adriana TomićOxford Vaccine Group, University of Oxford, Oxford, UK.
Astrid KrmpotićCenter for Proteomics, University of Rijeka, Faculty of Medicine, Rijeka, Croatia.
Markus HoffmannInfection Biology Unit, German Primate Center, Göttingen, Germany.ORCID http://orcid.org/0000-0003-4603-7696
Yotam Bar-OnDepartment of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Julia BoehmeInfection Immunology, Institute for Medical Microbiology and Hospital Hygiene, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany; Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Dunja BruderInfection Immunology, Institute for Medical Microbiology and Hospital Hygiene, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany; Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Thomas EbensenDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Linda BrunotteInstitute of Virology, Medical University Münster, Münster, Germany.
Stephan LudwigInstitute of Virology, Medical University Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-4490-3052
Martin MesserleInstitute of Virology, Hannover Medical School (MHH), Hannover, Germany.
Carlos GuzmanDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Ofer MandelboimDepartment of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Michael HustDepartment of Biotechnology, Institut für Biochemie, Biotechnologie und Bioinformatik, Technischen Universität Braunschweig, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-3418-6045
Stefan PöhlmannInfection Biology Unit, German Primate Center, Göttingen, Germany.ORCID http://orcid.org/0000-0001-6086-9136
Stipan JonjićCenter for Proteomics, University of Rijeka, Faculty of Medicine, Rijeka, Croatia.ORCID http://orcid.org/0000-0001-5003-3108
Luka Čičin-ŠainDepartment of Viral Immunology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. luka.cicin-sain@helmholtz-hzi.de.ORCID http://orcid.org/0000-0003-3978-778X
Helmholtz Centre for Infection Research · DEGerman Primate Center · DETechnion – Israel Institute of Technology · ILTechnische Universität Braunschweig · DEUniversity of Rijeka · HRGerman Center for Infection Research · DEMedizinische Hochschule Hannover · DEUniversity of Oxford · GB

Funding

Helmholtz Association PIE-0008
6 · The paper itself

Abstract

Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality. There remains a medical need for vaccines against these pathogens. CMV (cytomegalovirus) is a β-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8

Indexed as

Immunity, HumoralAnimalsAntibodies, NeutralizingAntibodies, ViralChlorocebus aethiopsCOVID-19COVID-19 VaccinesCytomegalovirusDogsFemaleHEK293 CellsHemagglutinin Glycoproteins, Influenza VirusHumansImmunity, CellularInfluenza A virusInfluenza VaccinesAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesHemagglutinin Glycoproteins, Influenza Virushemagglutinin, human influenza A virusInfluenza VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Cytomegalovirushumoral imunityInfluenzaSARS-CoV-2Vaccine vector

Identifiers

PMID34992275
PMCPMC8739032
OpenAlexW4225411516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.