ArticleNature biomedical engineering2022
Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer.
Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06012058 (Glaucoma Screening With Artificial Intelligence - A Randomized Clinical Trial Comparing Retinal Nerve Fiber Layer Optical Texture Analysis and Optic Disc Photography Assessment), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glaucoma Screening With Artificial Intelligence - A Randomized Clinical Trial Comparing Retinal Nerve Fiber Layer Optical Texture Analysis and Optic Disc Photography Assessment
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Changes in Retinal Nerve Fiber Layer Thickness in Patients With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.The clinical respiratory journal · 2025Pooled it
- Radiomics in ophthalmology: a systematic review.European radiology · 2025Pooled it
- Genetic analysis of imaging-derived phenotypes.Nature reviews. Genetics · 2026Review
- Retinal nerve fibre layer optical texture analysis: retinal nerve fibre bundle defect patterns and the extent of macular involvement across different stages of glaucoma.The British journal of ophthalmology · 2026Article
- Automatic Retinal Nerve Fiber Segmentation and the Influence of Intersubject Variability in Ocular Parameters on the Mapping of Retinal Sites to the Pointwise Orientation Angles.Journal of imaging · 2026Article
- Research on deep learning-based lesion identification in optical coherence tomography.BMC ophthalmology · 2026Article
- Automatic Algorithm-Aided Segmentation of Retinal Nerve Fibers Using Fundus Photographs.Journal of imaging · 2025Article
- Comparative of OCT and OCTA parameters in patients with early chronic angle-closure glaucoma and early pituitary adenoma.Scientific reports · 2024Article
- Article
- OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes.American journal of ophthalmology · 2024Article
- Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma.Journal of clinical medicine · 2024Review
- Normal-Tension Glaucoma Complicated by a Giant Internal Carotid-Ophthalmic Artery Aneurysm.Case reports in ophthalmological medicine · 2024Article
- Comparison of the retinal microvasculature between compressive and glaucomatous optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Cost-efficient and glaucoma-specifical model by exploiting normal OCT images with knowledge transfer learning.Biomedical optics express · 2023Article
- OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia-An American Ophthalmological Society Thesis.American journal of ophthalmology · 2023Article
- Discriminating Between Compressive Optic Neuropathy With Glaucoma-Like Cupping and Glaucomatous Optic Neuropathy Using OCT and OCTA.Translational vision science & technology · 2023Article
- Medical Application of Geometric Deep Learning for the Diagnosis of Glaucoma.Translational vision science & technology · 2023Article
- Optical Coherence Tomography and Optical Coherence Tomography Angiography: Essential Tools for Detecting Glaucoma and Disease Progression.Frontiers in ophthalmology · 2023Article
- Reverse translation of artificial intelligence in glaucoma: Connecting basic science with clinical applications.Frontiers in ophthalmology · 2023Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical diagnostic evaluation of optic neuropathies relies on the analysis of the thickness of the retinal nerve fibre layer (RNFL) by optical coherence tomography (OCT). However, false positives and false negatives in the detection of RNFL abnormalities are common. Here we show that an algorithm integrating measurements of RNFL thickness and reflectance from standard wide-field OCT scans can be used to uncover the trajectories and optical texture of individual axonal fibre bundles in the retina and to discern distinctive patterns of loss of axonal fibre bundles in glaucoma, compressive optic neuropathy, optic neuritis and non-arteritic anterior ischaemic optic neuropathy. Such optical texture analysis can detect focal RNFL defects in early optic neuropathy, as well as residual axonal fibre bundles in end-stage optic neuropathy that were indiscernible by conventional OCT analysis and by red-free RNFL photography. In a diagnostic-performance study, optical texture analysis of the RNFL outperformed conventional OCT in the detection of glaucoma, as defined by visual-field testing or red-free photography. Our findings show that optical texture analysis of the RNFL for the detection of optic neuropathies is highly sensitive and specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.