Evidence map›Paper›PMID 34992227›Full record

ArticleScientific reports2022

Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product.

Małgorzata Kowalska, Magdalena Woźniak, Michał Kijek, Paulina Mitrosz, Jerzy Szakiel, Paweł Turek

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
210.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2,098 citations in OpenAlex.

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  16. 125 Years of Aspirin: Status of Analytical Methods.Current pharmaceutical design · 2025
    Review
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  18. High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Małgorzata KowalskaDepartment of Management and Product Quality, Faculty of Chemical Engineering and Commodity Science, Kazimierz Pulaski University of Technology and Humanities, 27 Chrobrego St, 26-600, Radom, Poland. mkowalska7@vp.pl.
Magdalena WoźniakDepartment of Management and Product Quality, Faculty of Chemical Engineering and Commodity Science, Kazimierz Pulaski University of Technology and Humanities, 27 Chrobrego St, 26-600, Radom, Poland.
Michał KijekMedicofarma S.A., 13 Tarnobrzeska St, 26-613, Radom, Poland.
Paulina MitroszDepartment of Management and Product Quality, Faculty of Chemical Engineering and Commodity Science, Kazimierz Pulaski University of Technology and Humanities, 27 Chrobrego St, 26-600, Radom, Poland.
Jerzy SzakielDepartment of Non-Food Product Quality and Safety, Cracow University of Economics, Rakowicka St. 27, 31-510, Cracow, Poland.
Paweł TurekDepartment of Non-Food Product Quality and Safety, Cracow University of Economics, Rakowicka St. 27, 31-510, Cracow, Poland.
Kazimierz Pułaski University of Technology and Humanities in Radom · PLKrakow University of Economics · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The work mainly focused on a validation of the method for determining the content of salicylic acid and individual unknown impurities in new pharmaceutical product-tablets containing: 75, 100 or 150 mg of acetylsalicylic acid and glycine in the amount of 40 mg for each dosage. The separation of the components was carried out by means of HPLC, using a Waters Symmetry C18 column (4.6 × 250 mm, 5 μm) as the stationary phase. The mobile phase consisted of a mixture of 85% orthophosphoric acid, acetonitrile and purified water (2:400:600 V/V/V). Detection was carried out at a wavelength of 237 nm, with a constant flow rate of 1.0 ml min

Indexed as

Drug ContaminationAspirinChromatography, High Pressure LiquidGlycineLimit of DetectionReproducibility of ResultsSensitivity and SpecificityTabletsAspirinGlycineTablets

Identifiers

PMID34992227
PMCPMC8738756
OpenAlexW4205765055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.