Evidence map›Paper›PMID 34992142›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A quantitative framework reveals traditional laboratory growth is a highly accurate model of human oral infection.

Gina R Lewin, Kendall S Stocke, Richard J Lamont, Marvin Whiteley

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Bridging bench and bedside: translational omics ofEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Discovery ofmBio · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Simulated Media for Mimicking the Human Environment In Vitro.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025
    Review
  8. Article
  9. Article
  10. Towards improved biofilm models.Nature reviews. Microbiology · 2025
    Review
  11. Improvement of a mouse infection model to captureProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. We have a community problem.Journal of bacteriology · 2024
    Article
  13. Article
  14. Article
  15. Application of a quantitative framework to improve the accuracy of a bacterial infection model.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Precise spatial structure impacts antimicrobial susceptibility ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gina R LewinSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-1189-6696
Kendall S StockeDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-3147-5039
Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332; mwhiteley3@gatech.edu.
Georgia Institute of Technology · USUniversity of Louisville · US

Funding

MOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5M
P GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4M
Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
Metabolite sensing in a polymicrobial infectionR01DE020100 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2011 to 2022
$3.3M
Probing the impact of polymicrobial interactions on the virulence of an oral pathogenF32DE027281 · NIDCR · GEORGIA INSTITUTE OF TECHNOLOGY · PI LEWIN, GINA · 2017 to 2021
$215k
Probing the role of heterogeneity in streptococcal interactionsK99DE031018 · NIDCR · GEORGIA INSTITUTE OF TECHNOLOGY · PI LEWIN, GINA · 2021 to 2022
$120k
NIDCR NIH HHS F32 DE027281NIDCR NIH HHS K99 DE031018NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R01 DE020100NIDCR NIH HHS R01 DE023193
6 · The paper itself

Abstract

Bacterial behavior and virulence during human infection is difficult to study and largely unknown, as our vast knowledge of infection microbiology is primarily derived from studies using in vitro and animal models. Here, we characterize the physiology of

Indexed as

AnimalsBacteroidaceae InfectionsFimbriae, BacterialGingipain Cysteine EndopeptidasesHumansLaboratoriesMicePeriodontitisPorphyromonas gingivalisTranscriptomeVirulenceVirulence FactorsGingipain Cysteine EndopeptidasesVirulence Factorslaboratory modelsmetatranscriptomicsperiodontitisPorphyromonas gingivalis

Identifiers

PMID34992142
PMCPMC8764681
OpenAlexW4205150541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.