Observational studyGut2022
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.
Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Alcohol-Related Liver Disease After Metabolic Bariatric Surgery: Reassessing the Hidden Risk-A Meta-Analysis.Obesity surgery · 2026Pooled it
- Meta-analysis: Prevalence and impact of alcohol abstinence in alcohol-associated cirrhosis.Alimentary pharmacology & therapeutics · 2024Pooled it
- Cuproptosis: potential new direction in liver-related diseases research and treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Novel biomarkers for alcohol-associated liver disease and their implications across clinical settings.Clinical and molecular hepatology · 2026Review
- MSCs-derived CRABP2 regulates Treg/CXCL1 to ameliorate alcohol-induced liver injury.Cell communication and signaling : CCS · 2026Article
- Subchronic Alcohol Exposure Exacerbates Acetaminophen-Induced Acute Liver Injury via Macrophage-Mediated Inflammation and Mitochondrial Dysfunction.Mediators of inflammation · 2026Article
- Cholestasis in Alcohol-Associated Liver Disease.The American journal of pathology · 2026Review
- Interaction of inflammation and portal hypertension in cirrhosis progression.Nature reviews. Gastroenterology & hepatology · 2025Review
- GLP-1 receptor agonism results in reduction in hepatic ethanol metabolism.npj metabolic health and disease · 2025Article
- Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions.Nature communications · 2025Article
- Review
- Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000-2021.Clinical and molecular hepatology · 2025Article
- Alcohol-associated liver disease: Natural history, management and novel targeted therapies.Clinical and molecular hepatology · 2025Review
- Low incidence of cytolysin-positiveGut microbes reports · 2025Article
- Co-existing regeneration mechanisms in severe alcohol-related steatohepatitis.Translational gastroenterology and hepatology · 2025Article
- Neutrophil Recruitment via Hepatocyte IL-1α Drives NETs-Mediated AIM2 Hepatocyte Apoptosis in Alcohol-associated steatohepatitis.International journal of biological sciences · 2025Article
- QingGan LiDan capsules improved alcoholic liver injury by regulating liver lipid transport and oxidative stress in mice.Frontiers in pharmacology · 2025Article
- Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis.Journal of inflammation research · 2025Article
- Article
- Diagnosis of Alcohol Use Disorder and Alcohol-Associated Liver Disease.Clinics in liver disease · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors at 20 institutions in 14 countries.
Meritxell Ventura-CotsCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Josepmaria ArgemiCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Patricia D JonesDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Carolin LacknerInstitute of Pathology, Medical University of Graz, Graz, Austria.
Mohamed El HagDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Juan G AbraldesDivision of Gastroenterology, Liver Unit, University of Alberta, Edmonton, Alberta, Canada.
Edilmar AlvaradoCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Ana ClementeCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Samhita RaviCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Antonio AlvesDepartament of Pathology, Hospital Prof. Doutor Fernando Fonseca. Instituto de Anatomia Patologica, Faculdade de Medicina de Lisboa, Universidade de Lisboa, Lisboa, Portugal.
Mohamed AlboraieDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-8490-9822
Jose AltamiranoInternal Medicine, Hospital Quironsalud Barcelona, Barcelona, Spain.
Sergio BaraceCentro de investigación Médica Aplicada (CIMA), Universidad de Navarra, Hepatology Program, Pamplona, Spain.
Francisco BosquesHospital Sant José Tecnológico de Monterrey, Universidad Autonoma de Nuevo Leon, Monterrey, Monterrey, Mexico.ORCID 0000-0002-9795-7209
Robert BrownDivision of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, New York, USA.
Juan CaballeriaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
Joaquin CabezasGastroenterology and Hepatology Department Marques de Valdecilla University Hospital, Valdecilla Research Institute - IDIVAL, Santander, Santander, Spain.
Sofia CarvalhanaClínica Universitária de Gastrenterologia, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Helena Cortez-PintoClínica Universitária de Gastrenterologia, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Adilia CostaDepartment of Pathology, Hospital Santa Maria, Faculdade de Medicina de Lisboa, Universidade de Lisboa, Lisboa, Portugal.
Delphine DegréCentre de ressources biologiques (BB-0033-00027) Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Brussels, Belgium.
Carlos Fernandez-CarrilloCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Nathalie Ganne-CarrieLiver Unit, INSERM UMR 1162, Hôpitaux Universitaires Paris Seine Saint-Denis, APHP, Université paris 13 Sorbonne Paris Cité, Paris, France.
Guadalupe Garcia-TsaoSection of Digestive Diseases, Yale University, New Haven, Connecticut. Department of Veterans Affairs Connecticut Healthcare, New Haven, Connecticut, USA.
Joan GenescaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
John Koskinas2nd Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Nicolas LanthierService d'Hépato-Gastroentérologie, Cliniques universitaires Saint-Luc, UCLouvain, Bruxelles, Belgium.ORCID 0000-0002-7651-9314
Alexandre LouvetUniversity of Lille, Inserm, CHU Lille, U1286-INFINITI-Institute for Translational Research in Inflammation, F-590000, Lille, France.ORCID 0000-0002-5293-007X
Juan José LozanoCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
Michael R LuceyMedicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Steven MassonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-1041-9844
Philippe MathurinUniversity of Lille, Inserm, CHU Lille, U1286-INFINITI-Institute for Translational Research in Inflammation, F-590000, Lille, France.ORCID 0000-0002-8110-2898
Nahum Mendez-SanchezLiver Research Unit, Medica Sur Clinic & Foundation and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Rosa MiquelLiver Histopathology Laboratory, Institute of Liver Studies, Kings College London, London, UK.
Christophe MorenoDepartment of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme and Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.
Taofic MounajjedDepartment of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Gemma OdenaDivision of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Won KimDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea (the Republic of).
Pau Sancho-BruCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.ORCID 0000-0001-5569-9259
R Warren SandsCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Justyna SzafranskaDepartment of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Barcelona, Spain.
Laurine VersetDepartment of Pathology, Hôpital Erasme, Université Libre de Bruxelles, Bruxelles, Belgium.
Bern SchnablMedicine, University of California San Diego, La Jolla, California, USA.
Christine SempouxInstitute of Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Vijay ShahDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Debbie Lindsay ShawcrossLiver Sciences, James Black Centre, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College, London, UK.ORCID 0000-0001-6133-4619
Rudolf E StauberDepartment of Internal Medicine, Medical University of Graz, Graz, Austria.
Beate K StraubInstitute of Pathology, Universities of Mainz and Heidelberg, Mainz, Germany.
Elizabeth VernaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.
Dina TiniakosInstitute of Cellular Medicine, Translational and Clinical Research Institute, Newcastle Univsersity, Newcastle upon Tyne, UK.
Eric TrépoDepartment of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme and Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.
Victor VargasCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
Càndid VillanuevaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
John T WoosleyPathology Department, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Marianne ZiolCentre de ressources biologiques (BB-0033-00027) Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bondy, France.
Sebastian MuellerSalem Medical Center and Center for Alcohol Research, University of Heidelberg, Heidelberg, Germany.
Peter StärkelService d'Hépato-Gastroentérologie, Cliniques universitaires Saint-Luc, UCLouvain, Brussels, Belgium.
Ramon BatallerCenter for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA BATALLER@pitt.edu.ORCID 0000-0002-1119-7799
Universitat Autònoma de Barcelona · ESUniversity of Lisbon · PTUniversity of Pittsburgh Medical Center · USCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESInserm · FRUniversité Libre de Bruxelles · BECliniques Universitaires Saint-Luc · BEKing's College London · GBMayo Clinic · USMedical University of Graz · ATNational and Kapodistrian University of Athens · GRUniversity of North Carolina at Chapel Hill · USAl-Azhar University · EGAssistance Publique – Hôpitaux de Paris · FRColumbia University Irving Medical Center · USCornell University · USHeidelberg University · DEHôpitaux Iris Sud · BEHospital Clínic de Barcelona · ESHospital de Sant Pau · ES
Funding
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MPittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8MMolecular Subtypes for Targeted Therapies in Alcoholic HepatitisU01AA021908 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATALLER, RAMON · 2013 to 2017
$6.0MMIF in progression and treatment of ALDU01AA020821 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2012 to 2016
$2.1MNIAAA NIH HHS P50 AA011999NIAAA NIH HHS U01 AA020821NIAAA NIH HHS U01 AA021908NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK120515NIDDK NIH HHS P30 DK120531
Abstract
objectiveAlcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking.
designTwo large cohorts of patients were recruited in an international, observational multicentre study: a retrospective cohort of patients with ndALD (n=110) and a prospective cohort of patients with AH (n=225). Clinical, analytical, immunohistochemistry and hepatic RNA microarray analysis of both disease phenotypes were performed.
resultsAge and mean alcohol intake were similar in both groups. AH patients had greater aspartate amino transferase/alanine amino transferase ratio and lower gamma-glutamyl transferase levels than in ndALD patients. Patients with AH demonstrated profound liver failure and increased mortality. One-year mortality was 10% in ndALD and 50% in AH. Histologically, steatosis grade, ballooning and pericellular fibrosis were similar in both groups, while advanced fibrosis, Mallory-Denk bodies, bilirubinostasis, severe neutrophil infiltration and ductular reaction were more frequent among AH patients. Transcriptome analysis revealed a profound gene dysregulation within both phenotypes when compare to controls. While ndALD was characterised by deregulated expression of genes involved in matrisome and immune response, the development of AH resulted in a marked deregulation of genes involved in hepatocyte reprogramming and bile acid metabolism.
conclusionsDespite comparable alcohol intake, AH patients presented with worse liver function compared with ndALD patients. Bilirubinostasis, severe fibrosis and ductular reaction were prominent features of AH. AH patients exhibited a more profound deregulation of gene expression compared with ndALD patients.
Indexed as
Hepatitis, AlcoholicFibrosisHumansLiverProspective StudiesRetrospective Studiesalcoholalcoholic liver diseasealcohol-induced injurygene expressionhistopathology
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