Evidence map›Paper›PMID 34992132›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model.

Eri Iwasawa, Farrah N Brown, Crystal Shula, Fatima Kahn, Sang Hoon Lee, Temugin Berta, David R Ladle, Kenneth Campbell, Francesco T Mangano, June Goto

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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  11. Effects ofInternational journal of molecular sciences · 2023
    Article
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  15. A neural stem cell paradigm of pediatric hydrocephalus.Cerebral cortex (New York, N.Y. : 1991) · 2023
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Eri IwasawaDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45242.
Farrah N BrownDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45242.
Crystal ShulaDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45242.
Fatima KahnDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45242.
Sang Hoon LeePain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, Ohio, 45242.
Temugin BertaPain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, Ohio, 45242.
David R LadleDepartment of Neuroscience, Cell Biology, and Physiology, Wright State University, Dayton, Ohio, 45435.
Kenneth CampbellDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45242.ORCID 0000-0001-5666-8008
Francesco T ManganoDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45242.
June GotoDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45242 june.goto@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · USWright State University · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
STING & PAIN: exploring a viral signaling protein in nociception and neuropathyR21NS121946 · NINDS · UNIVERSITY OF CINCINNATI · PI BERTA, TEMUGIN · 2021 to 2021
$445k
NCATS NIH HHS UL1 TR001425NINDS NIH HHS R21 NS121946
6 · The paper itself

Abstract

Neonatal hydrocephalus presents with various degrees of neuroinflammation and long-term neurologic deficits in surgically treated patients, provoking a need for additional medical treatment. We previously reported elevated neuroinflammation and severe periventricular white matter damage in the

Indexed as

HydrocephalusMicrogliaAnimalsAnimals, NewbornAnti-Inflammatory AgentsDisease Models, AnimalFemaleHumansIndazolesMicePregnancyPropionatesAnti-Inflammatory AgentsbindaritIndazolesPropionatesbindaritmicroglianeonatal hydrocephaluswhite matter injury

Identifiers

PMID34992132
PMCPMC8896558
OpenAlexW4206457334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.