Evidence map›Paper›PMID 34992071›Full record

ArticleBMJ open gastroenterology2022

Effect of COVID-19 on presentations of decompensated liver disease in Scotland.

Thomas Manship, Paul N Brennan, Iona Campbell, Stewart Campbell, Thomas Clouston, John F Dillon, Ewan Forrest, Andrew Fraser, Tee Lin Goh, Michael Johnston and 6 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

Thomas ManshipCentre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, UK.
Paul N BrennanCentre for Regenerative Medicine, The University of Edinburgh Edinburgh Medical School, Edinburgh, UK p.z.brennan@dundee.ac.uk.ORCID http://orcid.org/0000-0001-8368-1478
Iona CampbellCentre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, UK.
Stewart CampbellDepartment of Gastroenterology, University Hospital Hairmyres, East Kilbride, UK.
Thomas CloustonThe University of Edinburgh Edinburgh Medical School, Edinburgh, UK.
John F DillonGut Group, Ninewells Hospital and Medical School, Dundee, UK.
Ewan ForrestDepartment of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK.
Andrew FraserDepartment of Gastroenterology, NHSGGC, Glasgow, UK.
Tee Lin GohDumfries and Galloway Acute Hospitals, Dumfries, Dumfries and Galloway, UK.
Michael JohnstonDepartment of Gastroenterology, NHSGGC, Glasgow, UK.
Muhammad I KhanDepartment of Gastroenterology, NHSGGC, Glasgow, UK.
Victoria LivieGut Group, Ninewells Hospital and Medical School, Dundee, UK.
Iain A MurrayDepartment of Gastroenterology, Dumfries and Galloway Acute Hospitals, Dumfries, UK.ORCID http://orcid.org/0000-0002-1795-3647
Jayne SaundersGastroenterology, NHS Lanarkshire, Lanarkshire, Scotland.
Debbie TrolandGastroenterology, NHS Greater Glasgow and Clyde, Glasgow, Scotland.
Ken J SimpsonCentre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, UK.
NHS Greater Glasgow and Clyde · GBEdinburgh Royal Infirmary · GBNHS Dumfries and Galloway · GBGlasgow Royal Infirmary · GBHairmyres Hospital · GBMRC Centre for Regenerative Medicine · GBNHS Lanarkshire · GBNinewells Hospital · GBUniversity of Dundee · GBUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSARS-CoV-2 and consequent pandemic has presented unique challenges. Beyond the direct COVID-related mortality in those with liver disease, we sought to determine the effect of lockdown on people with liver disease in Scotland. The effect of lockdown on those with alcohol-related disease is of interest; and whether there were associated implications for a change in alcohol intake and consequent presentations with decompensated disease.

methodsWe performed a retrospective analysis of patients admitted to seven Scottish hospitals with a history of liver disease between 1 April and 30 April 2020 and compared across the same time in 2017, 2018 and 2019. We also repeated an intermediate assessment based on a single centre to examine for delayed effects between 1 April and 31 July 2020.

resultsWe found that results and outcomes for patients admitted in 2020 were similar to those in previous years in terms of morbidity, mortality, and length of stay. In the Scotland-wide cohort: admission MELD (Model for End-stage Liver Disease) (16 (12-22) vs 15 (12-19); p=0.141), inpatient mortality ((10.9% vs 8.6%); p=0.499) and length of stay (8 days (4-15) vs 7 days (4-13); p=0.140). In the Edinburgh cohort: admission MELD (17 (12-23) vs 17 (13-21); p=0.805), inpatient mortality ((13.7% vs 10.1%; p=0.373) and length of stay (7 days (4-14) vs 7 days (3.5-14); p=0.525)).

conclusionThis assessment of immediate and medium-term lockdown impacts on those with chronic liver disease suggested a minimal effect on the presentation of decompensated liver disease to secondary care.

Indexed as

COVID-19End Stage Liver DiseaseCommunicable Disease ControlHumansRetrospective StudiesSARS-CoV-2ScotlandSeverity of Illness Indexalcoholic liver diseaseCOVID-19liver

Identifiers

PMID34992071
PMCPMC8739538
OpenAlexW4206248545

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.