ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2022
A prospective, first-in-human use of the NeVa mechanical thrombectomy device for patients with acute coronary syndromes.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Guide-Extension Catheter-Assisted Bail-Out Thrombus Aspiration During PCI for Thrombus-Rich Acute Coronary Syndromes: Contemporary Review and Clinical Case Examples.Journal of clinical medicine · 2026Review
- Guidewire Retrieval Device as Bailout for Massive Coronary Thrombus in STEMI.JACC. Case reports · 2026Article
- Efficacy and Safety of Solitaire Revascularization Device in Managing Refractory Thrombus in Acute Coronary Syndrome.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Thrombectomy in acute myocardial infarction: Current evidence, challenges, and emerging technologies.World journal of clinical cases · 2025Review
- Pharmacological and Interventional Prevention and Treatment of Microvascular Obstruction Following Primary PCI in STEMI.Journal of cardiovascular development and disease · 2025Review
- Intravascular ultrasound-guided Lawnest catcher in pulling out heavy thrombi from right coronary artery.Journal of geriatric cardiology : JGC · 2025Article
- Coronary stent retriever-assisted thrombectomy.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Initial experience with a novel stent-based mechanical thrombectomy device for management of acute myocardial infarction cases with large thrombus burden.Cardiovascular intervention and therapeutics · 2024Article
- The Use of Thrombectomy during Primary Percutaneous Coronary Intervention: Resurrecting an Old Concept in Contemporary Practice.Journal of clinical medicine · 2024Review
- Neurointerventional tools and techniques for coronary thrombus removal. A case-based review.Journal of cardiology cases · 2022Article
- Complex Coronary Interventions: Are We Reaching a Plateau?Journal of personalized medicine · 2022Article
- Intracoronary thrombus in ST-segment elevation myocardial infarction: Practical management strategies for the interventional cardiologist.Indian heart journalReview
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Authors and funding
11 authors.
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Abstract
backgroundThere is no established technique for managing large thrombus burden (LTB) in patients with acute coronary syndrome (ACS).
aimsThe aim of this study was to assess the safety and efficacy of the NeVa (Vesalio) mechanical thrombectomy device (MTD) in ACS patients with LTB.
methodsConsecutive patients with ACS and LTB were treated with the NeVa MTD as the primary vessel recanalisation and thrombus removal modality, followed by conventional intervention. We further developed a bench model and applied to a subset of patients, a vacuum-assisted aspiration technique, exploiting 6 Fr-compatible conventional guiding catheter extensions, as an adjudicative manoeuvre to the use of stent-based MTD. A core laboratory reviewed the angiographic images for procedural complications, Thrombolysis In Myocardial Infarction (TIMI) flow, myocardial blush grade (MBG) and TIMI thrombus grade (TTG).
resultsBetween November 2019 and March 2021, 61 patients underwent thrombectomy with the NeVa device. Non-flow limiting and reversible coronary spasm occurred in 14 (23%) patients. One patient (#10) suffered from side branch embolisation, which was successfully treated with the NeVa, triggering the development of a vacuum-assisted aspiration technique in a bench model, which was then applied to the subsequent 51 patients. No other device-related complications occurred. After NeVa use, TIMI flow <3 decreased from 68.3% at baseline to 10.3% (p<0.001), MBG <2 from 65% to 27.6% (p<0.001), TTG ≥3 from 96.7% to 43.2% (p<0.001), respectively.
conclusionsIn patients with LTB, the NeVa MTD was safe and associated with high rates of vessel recanalisation and thrombus removal. The concomitant use of vacuum-assisted aspiration has potential to improve the effectiveness and safety of the technique.
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