Evidence map›Paper›PMID 34991777›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2022

Serological responses to COVID-19 Comirnaty booster vaccine, London, United Kingdom, September to December 2021.

Georgina Ireland, Heather Whitaker, Shamez N Ladhani, Frances Baawuah, Sathyvani Subbarao, Ezra Linley, Lenesha Warrener, Michelle O'Brien, Corinne Whillock, Oliver Martin and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Georgina IrelandImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Heather WhitakerStatistics, Modelling and Economics Department, UK Health Security Agency, London, United Kingdom.
Shamez N LadhaniImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Frances BaawuahImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Sathyvani SubbaraoImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Ezra LinleySero-Epidemiology Unit, UK Health Security Agency, Manchester, United Kingdom.
Lenesha WarrenerVirus Reference Department, UK Health Security Agency, London, United Kingdom.
Michelle O'BrienBrondesbury Medical Centre, Kilburn, London, United Kingdom.
Corinne WhillockImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Oliver MartinImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Paul MossInstitute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, United Kingdom.
Mary E RamsayImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Gayatri AmirthalingamImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
Kevin E BrownImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, United Kingdom.
UK Health Security Agency · GBNational Health Service · GBSt George's, University of London · GBUniversity of Birmingham · GB

Funding

Medical Research Council MC_PC_20060
6 · The paper itself

Abstract

Serum samples were collected pre- and post-booster vaccination with Comirnaty in 626 participants (aged ≥ 50 years) who had received two Comirnaty doses < 30 days apart, two Comirnaty doses ≥ 30 days apart or two Vaxzevria doses ≥ 30 days apart. Irrespective of primary vaccine type or schedule, spike antibody GMTs peaked 2-4 weeks after second dose, fell significantly ≤ 38 weeks later and rose above primary immunisation GMTs 2-4 weeks post-booster. Higher post-booster responses were observed with a longer interval between primary immunisation and boosting.

Indexed as

COVID-19COVID-19 VaccinesHumansLondonSARS-CoV-2United KingdomCOVID-19 VaccinesAntibodyAstraZeneca, Comirnaty, VaxzevriaCOVID-19COVID-VaccineImmunityPfizerSpike Protein

Identifiers

PMID34991777
PMCPMC8739342
OpenAlexW4205272402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.