Evidence map›Paper›PMID 34991713›Full record

ArticleAddiction science & clinical practice2022

Prevalence of marijuana use in pregnant women with concurrent opioid use disorder or alcohol use in pregnancy.

Kimberly Page, Cristina Murray-Krezan, Lawrence Leeman, Mary Carmody, Julia M Stephen, Ludmila N Bakhireva

Open access · goldAbstract read
In one paragraph

Article in Addiction science & clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  10. Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kimberly PageDivision of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, School of Medicine, University of New Mexico MSC 10 5550, Albuquerque, NM, 87131, USA. pagek@salud.unm.edu.ORCID 0000-0002-7120-1673
Cristina Murray-KrezanDivision of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, School of Medicine, University of New Mexico MSC 10 5550, Albuquerque, NM, 87131, USA.
Lawrence LeemanDepartment of Family and Community Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
Mary CarmodyDivision of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, School of Medicine, University of New Mexico MSC 10 5550, Albuquerque, NM, 87131, USA.
Julia M StephenThe Mind Research Network a Division of Lovelace Biomedical Research Institute, Albuquerque, NM, USA.
Ludmila N BakhirevaDivision of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, School of Medicine, University of New Mexico MSC 10 5550, Albuquerque, NM, 87131, USA.
University of New Mexico · USMind Research Network · US

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Southwest Clinical Trials Node: Clinical Research and Practice to Address Substance Use in Diverse, Rural, and Underserved PopulationsUG1DA049468 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MARIA ADELA GRANDO, Kimberly Page · 2019 to 2026
$12.5M
The effect of the COVID-19 pandemic on alcohol use and psycho-somatic health in pregnant and postpartum women with intersecting vulnerabilities.R01AA021771 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BAKHIREVA, LUDMILA NICOLE · 2013 to 2022
$6.5M
6/6 Planning for the HEALthy Early Development StudyR34DA050237 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BAKHIREVA, LUDMILA NICOLE, LEEMAN, LAWRENCE M · 2019 to 2019
$542k
NCATS NIH HHS 1UL TR001449NCATS NIH HHS UL1 TR001449NIAAA NIH HHS R01 AA021771NIDA NIH HHS 1R34DA050237NIDA NIH HHS R34 DA050237NIDA NIH HHS UG1 DA049468
6 · The paper itself

Abstract

backgroundA quarter of pregnant women use alcohol, 6.5/1000 deliveries are affected by opioid use disorder (OUD), and the prevalence of cannabis use in pregnant women is increasing. However, marijuana co-exposure in polysubstance-using women is not well described.

methodsThe well-characterized ENRICH-1 cohort (n = 251), which focused on the effects of two primary exposures of interest-opioids and alcohol, was used to (1) estimate the prevalence/frequency of marijuana use in those with OUD and/or alcohol use, and (2) examined correlates of marijuana use. Participants were classified into an OUD group (n = 125), Alcohol group (n = 69), and concurrent OUD and Alcohol (OUD + Alcohol) group (n = 57). Self-report and biomarkers ascertained substance use. Multivariable logistic regression identified correlates of marijuana use.

resultsThe prevalence of any marijuana use in pregnancy was 43.2%, 52.6%, and 46.4% in the OUD, OUD + Alcohol, and Alcohol groups, respectively. Correspondingly, weekly or daily use was reported by 19.4%, 21.0%, and 24.6% of participants. In the OUD and OUD + Alcohol groups, the proportion of women using marijuana was significantly higher in those taking buprenorphine (45.8% and 58.3%, respectively) compared to women using methadone (37.5% and 42.9%, respectively). Mean maternal age was lower in women who used marijuana in all three groups compared to non-marijuana users. Independent correlates of marijuana use (controlling for group, race/ethnicity, education, and smoking) were maternal age (adjusted Odds Ratio (aOR) per 5-year increment 0.61; (95% CI 0.47, 0.79)), and polysubstance use (aOR 2.02; 95% CI 1.11, 3.67). There was a significant interaction between partnership status and group: among women who were not in a partnership, those in the OUD and OUD + Alcohol groups had lower odds of marijuana use relative to the Alcohol group. For women in the Alcohol group, partnered women had lower odds of marijuana use than un-partnered women (aOR 0.12; 95% CI: 0.02, 0.68).

conclusionsResults indicate a relatively high prevalence and frequency of marijuana use in pregnant women being treated for OUD and/or women consuming alcohol while pregnant. These results highlight the need for ongoing risk reduction strategies addressing marijuana use for pregnant women receiving OUD treatment and those with alcohol exposure.

Indexed as

BuprenorphineMarijuana UseOpioid-Related DisordersFemaleHumansOpiate Substitution TreatmentPregnancyPregnant PeoplePrevalenceBuprenorphineAlcoholCannabisMarijuanaOpioidsPregnancy

Identifiers

PMID34991713
PMCPMC8734065
OpenAlexW4206179672

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.