Evidence map›Paper›PMID 34991660›Full record

ArticleCritical care (London, England)2022

Association between unmet medication needs after hospital discharge and readmission or death among acute respiratory failure survivors: the addressing post-intensive care syndrome (APICS-01) multicenter prospective cohort study.

Samuel M Brown, Victor D Dinglas, Narjes Akhlaghi, Somnath Bose, Valerie Banner-Goodspeed, Sarah Beesley, Danielle Groat, Tom Greene, Ramona O Hopkins, Mustafa Mir-Kasimov and 5 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03738774 (Addressing Post-Intensive Care Syndrome Among Survivors of COVID), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03738774 active not recruitingnot on this map

Addressing Post-Intensive Care Syndrome Among Survivors of COVID (APICS-COVID)

TypeobservationalSponsorVanderbilt University Medical CenterRan2019 to 2026Enrolled200ConditionsPost Intensive Care Syndrome
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Samuel M BrownPulmonary and Critical Care Medicine, Intermountain Medical Center, Salt Lake City, UT, USA. Samuel.Brown@imail.org.ORCID 0000-0003-1206-6261
Victor D DinglasOutcomes After Critical Illness and Surgery (OACIS) Group and Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Narjes AkhlaghiDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Somnath BoseBeth Israel Deaconess Medical Center, Boston, MA, USA.
Valerie Banner-GoodspeedBeth Israel Deaconess Medical Center, Boston, MA, USA.
Sarah BeesleyPulmonary and Critical Care Medicine, Intermountain Medical Center, Salt Lake City, UT, USA.
Danielle GroatPulmonary and Critical Care Medicine, Intermountain Medical Center, Salt Lake City, UT, USA.
Tom GreeneBiostatistics and Epidemiology, University of Utah, Salt Lake City, UT, USA.
Ramona O HopkinsCenter for Humanizing Critical Care, Intermountain Medical Center, Salt Lake City, UT, USA.
Mustafa Mir-KasimovPulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT, USA.
Carla M SevinVanderbilt University Medical Center, Nashville, TN, USA.
Alison E TurnbullOutcomes After Critical Illness and Surgery (OACIS) Group and Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
James C JacksonVanderbilt University Medical Center, Nashville, TN, USA.
Dale M NeedhamOutcomes After Critical Illness and Surgery (OACIS) Group and Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
APICS-01 Study Team

Funding

U.S. Department of Defense W81XWH-17-PRMRP-IIRA
6 · The paper itself

Abstract

introductionSurvivors of acute respiratory failure (ARF) commonly experience long-lasting physical, cognitive, and/or mental health impairments. Unmet medication needs occurring immediately after hospital discharge may have an important effect on subsequent recovery. METHODS AND ANALYSIS: In this multicenter prospective cohort study, we enrolled ARF survivors who were discharged directly home from their acute care hospitalization. The primary exposure was unmet medication needs. The primary outcome was hospital readmission or death within 3 months after discharge. We performed a propensity score analysis, using inverse probability weighting for the primary exposure, to evaluate the exposure-outcome association, with an a priori sample size of 200 ARF survivors.

resultsWe enrolled 200 ARF survivors, of whom 107 (53%) were female and 77 (39%) were people of color. Median (IQR) age was 55 (43-66) years, APACHE II score 20 (15-26) points, and hospital length of stay 14 (9-21) days. Of the 200 participants, 195 (98%) were in the analytic cohort. One hundred fourteen (57%) patients had at least one unmet medication need; the proportion of medication needs that were unmet was 6% (0-15%). Fifty-six (29%) patients were readmitted or died by 3 months; 10 (5%) died within 3 months. Unmet needs were not associated (risk ratio 1.25; 95% CI 0.75-2.1) with hospital readmission or death, although a higher proportion of unmet needs may have been associated with increased hospital readmission (risk ratio 1.7; 95% CI 0.96-3.1) and decreased mortality (risk ratio 0.13; 95% CI 0.02-0.99). DISCUSSION: Unmet medication needs are common among survivors of acute respiratory failure shortly after discharge home. The association of unmet medication needs with 3-month readmission and mortality is complex and requires additional investigation to inform clinical trials of interventions to reduce unmet medication needs. Study registration number: NCT03738774 . The study was prospectively registered before enrollment of the first patient.

Indexed as

Patient DischargeRespiratory InsufficiencyAgedCohort StudiesCritical IllnessFemaleHospitalsHumansMiddle AgedPatient ReadmissionProspective StudiesSurvivorsAcute respiratory failureDischarge planningHealth services researchLong-term outcomes

Identifiers

PMID34991660
PMCPMC8738999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.