ArticleJournal of nanobiotechnology2022
Hydrogel composite scaffolds achieve recruitment and chondrogenesis in cartilage tissue engineering applications.
Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 106 citations in OpenAlex.
- Multifunctional hydrogel scaffolds for endogenous osteochondral regeneration.Regenerative therapy · 2026Review
- Liquid-Responsive Shape-Memory Nanofiber-Reinforced Scaffolds for Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Exploring cartilage development and disease models: applications of cartilage organoids.Inflammation and regeneration · 2026Review
- Enhancing the regenerative potential of MSC-derived exosomes via 3D microenvironment modulation for cartilage repair.Materials today. Bio · 2026Article
- Innovative Technologies for Articular Cartilage Repair: Research, Development, and Clinical Translation-A Narrative Review.Journal of functional biomaterials · 2026Review
- Self-Assembled Hydrogel from Pyrene-Modified Peptide as 3D Matrices for Neuronal Cell.ACS applied bio materials · 2026Article
- Article
- Engineering conformational transitions in silk fibroin hydrogels to create advanced dynamic microenvironments for biomedical applications.Regenerative biomaterials · 2026Review
- Transcriptomic analysis reveals distinct molecular signatures and regulatory networks of osteoarthritic chondrocytes versus mesenchymal stem cells during chondrogenesis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025Article
- Double-Network Bilayer Hydrogel Loaded with Puerarin and Curcumin for Osteochondral Repair.ACS omega · 2025Article
- Recent advances in hydrogel-assisted treatment of malignant bone tumors.Materials today. Bio · 2025Review
- A sequential drug delivery system based on silk fibroin scaffold for effective cartilage repair.Bioactive materials · 2025Article
- The Use of Gelatin Methacrylate (GelMA) in Cartilage Tissue Engineering: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2025Review
- Photobiomodulation in Promoting Cartilage Regeneration.International journal of molecular sciences · 2025Review
- Precision repair of zone-specific meniscal injuries using a tunable extracellular matrix-based hydrogel system.Bioactive materials · 2025Article
- Article
- Single BMSC-derived cartilage organoids for gradient heterogeneous osteochondral regeneration by leveraging native vascular microenvironment.Journal of nanobiotechnology · 2025Article
- An "EVs-in-ECM" mimicking system orchestrates transcription and translation of RUNX1 for in-situ cartilage regeneration.Materials today. Bio · 2025Article
- Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease.Journal of orthopaedic translation · 2025Review
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe regeneration and repair of articular cartilage remains a major challenge for clinicians and scientists due to the poor intrinsic healing of this tissue. Since cartilage injuries are often clinically irregular, tissue-engineered scaffolds that can be easily molded to fill cartilage defects of any shape that fit tightly into the host cartilage are needed.
methodIn this study, bone marrow mesenchymal stem cell (BMSC) affinity peptide sequence PFSSTKT (PFS)-modified chondrocyte extracellular matrix (ECM) particles combined with GelMA hydrogel were constructed.
resultsIn vitro experiments showed that the pore size and porosity of the solid-supported composite scaffolds were appropriate and that the scaffolds provided a three-dimensional microenvironment supporting cell adhesion, proliferation and chondrogenic differentiation. In vitro experiments also showed that GelMA/ECM-PFS could regulate the migration of rabbit BMSCs. Two weeks after implantation in vivo, the GelMA/ECM-PFS functional scaffold system promoted the recruitment of endogenous mesenchymal stem cells from the defect site. GelMA/ECM-PFS achieved successful hyaline cartilage repair in rabbits in vivo, while the control treatment mostly resulted in fibrous tissue repair.
conclusionThis combination of endogenous cell recruitment and chondrogenesis is an ideal strategy for repairing irregular cartilage defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.