Evidence map›Paper›PMID 34991596›Full record

ArticleJournal of nanobiotechnology2022

Atom-precise fluorescent copper cluster for tumor microenvironment targeting and transient chemodynamic cancer therapy.

Zhenzhen Yang, Anli Yang, Wang Ma, Kai Ma, Ya-Kun Lv, Peng Peng, Shuang-Quan Zang, Bingjie Li

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Ligand-Engineered CuSmall (Weinheim an der Bergstrasse, Germany) · 2026
    Article
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  3. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Zhenzhen Yang *Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Anli Yang *Department of Breast Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Wang MaDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Kai MaHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Ya-Kun LvHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Peng PengDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. ppeng@zzu.edu.cn.
Shuang-Quan ZangHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. zangsqzg@zzu.edu.cn.
Bingjie LiDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. bingjieli1991@outlook.com.ORCID http://orcid.org/0000-0002-6540-5557

Funding

China National Funds for Distinguished Young Scientists 21825106National Natural Science Foundation of China 22005273National Natural Science Foundation of China 802073168
6 · The paper itself

Abstract

backgroundReactive oxygen species (ROS) have been widely studied for cancer therapy. Nevertheless, instability and aspecific damages to cellular biomolecules limit the application effect. Recently, significant research efforts have been witnessed in the flourishing area of metal nanoclusters (NCs) with atomically precise structures for targeted release of ROS but few achieved success towards targeting tumor microenvironment.

resultsIn this work, we reported an atomically precise nanocluster Cu

conclusionsThis work not only reported a promising candidate for chemodynamic cancer therapy, but also paved the route to address clinical issues at the atomic level.

Indexed as

CopperFluorescent DyesNanoparticlesAnimalsAntineoplastic AgentsCell Line, TumorDrug Delivery SystemsFemaleMiceMice, Inbred BALB CPhotochemotherapyReactive Oxygen SpeciesTumor MicroenvironmentAntineoplastic AgentsCopperFluorescent DyesReactive Oxygen SpeciesCancer therapyNano clustersROSSustainable releaseTargeting property

Identifiers

PMID34991596
PMCPMC8734230

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.