ArticleBMC public health2022
Prevalence and incidence rates of laboratory-confirmed hepatitis B infection in South Africa, 2015 to 2019.
Article in BMC public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Progress towards the elimination of vertical transmission of HIV, syphilis and hepatitis B in 21 high-burden countries.Journal of the International AIDS Society · 2026Review
- Hepatitis B immunity and response to booster vaccination in South African students following childhood immunisation.Southern African journal of infectious diseases · 2026Article
- Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo.Tropical medicine and health · 2025Article
- Knowledge, attitudes and practices to hepatitis B among South African primary healthcare staff.African journal of primary health care & family medicine · 2025Article
- The contribution of PrEP programmes to triple elimination efforts: a cross-sectional study of status and opportunities.Frontiers in reproductive health · 2025Article
- EFFECTIVENESS OF HERBAL AND CONVENTIONAL MANAGEMENT INTERVENTIONS OF HEPATITIS B VIRUS.African journal of infectious diseases · 2025Article
- Hepatitis B infection (HBsAg and HBeAg) status among women attending antenatal care at public healthcare facilities of South Africa, 2017.PLOS global public health · 2025Article
- Hepatitis B seroprevalence among HIV-positive adults in the Free State, South Africa.Southern African journal of HIV medicine · 2025Article
- Seroprevalence and Predictors of Hepatitis B and C Virus Infections Among Patients with Chronic Liver Diseases in Dodoma Region, Tanzania: A Cross-Sectional Study.Hepatic medicine : evidence and research · 2025Article
- People living with HIV co-infected with HBV at the Nkembo Outpatient Treatment Center, Gabon: prevalence and associated factors.Frontiers in public health · 2025Article
- Prevalence of hepatitis B virus infection and treatment eligibility in Lesotho, Southern Africa: a population-based cross-sectional study with case-based follow-up.BMJ public health · 2024Article
- The prevalence of hepatitis B virus, human T-lymphotropic virus and human immunodeficiency virus in patients receiving blood transfusions in South Africa.Vox sanguinis · 2024Article
- Hepatitis B Viral Infection and its Associated Factors among Population Aged at Least 15 Years in Three Selected Cities of Burundi.The East African health research journal · 2024Article
- HIV/STD prevalence and test uptake among african in Guangzhou, China: an analysis of data from hospital-based surveillance.BMC infectious diseases · 2023Article
- Hepatitis B infection status among South Africans attending public health facilities over a five-year period: 2015 to 2019.PLOS global public health · 2023Article
- Hepatitis B Virus Immunity Gap: A Six-Year Laboratory Data Review of Hepatitis B Serological Profiles in Gauteng Province, South Africa.Advances in virology · 2023Article
- Low prevalence of hepatitis B virus infection in HIV-uninfected pregnant women in Cape Town, South Africa: implications for oral pre-exposure prophylaxis roll out.BMC infectious diseases · 2022Article
- Hepatocellular Carcinoma in Africa: Challenges and Opportunities.Frontiers in medicine · 2022Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis B virus (HBV), a global public health threat, is targeted for elimination by 2030. As national HBV prevalence and incidence is lacking for South Africa, our study aimed to provide such data in the public health sector.
methodsWe analysed laboratory-confirmed HBV data from 2015 to 2019 to determine annual prevalence and incidence rates of HBV infection per 100,000 population, HBsAg and anti-HBc IgM test positivity rates, and HBsAg and anti-HBc IgM testing rates per 100,000 population. Time trend and statistical analyses were performed on HBsAg and anti-HBc IgM test positivity rates.
resultsThe national prevalence rate of HBV infection per 100,000 population increased from 56.14 in 2015 to 67.76 in 2019. Over the five years, the prevalence rate was higher in males than females, highest amongst individuals 25 to 49 years old and highest in Gauteng province. The HBsAg test positivity rate dropped from 9.77% in 2015 to 8.09% in 2019. Over the five years, the HBsAg test positivity rate was higher in males than females, amongst individuals 25 to 49 years old and amongst individuals of Limpopo province. Amongst HBsAg positive children under 5 years old, the majority (65.7%) were less than a year old. HBsAg testing rates per 100,000 population were higher in females under 45 years of age and in males 45 years and above. The national incidence rate of acute HBV infection per 100,000 population dropped from 3.17 in 2015 to 1.69 in 2019. Over the five-year period, incidence rates were similar between males and females, highest amongst individuals 20 to 39 years old and highest in Mpumalanga province. Amongst individuals 20 to 24 years old, there was a substantial decline in the incidence and anti-HBc IgM test positivity rates over time. Anti-HBc IgM testing rates per 100,000 population were higher in females under 40 years of age and in males 40 years and above.
conclusionCritical to hepatitis B elimination is strengthened infant vaccination coverage and interruption of vertical transmission. Transmission of HBV infection in adults may be reduced through heightened awareness of transmission routes and prevention measures.
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