Evidence map›Paper›PMID 34991496›Full record

ArticleBMC infectious diseases2022

Causes of death and associated factors over a decade of follow-up in a cohort of people living with HIV in rural Tanzania.

Getrud Joseph Mollel, Lilian Moshi, Hoda Hazem, Anna Eichenberger, Olivia Kitau, Herry Mapesi, Tracy R Glass, Daniel Henry Paris, Maja Weisser, Fiona Vanobberghen

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Causes of death in people living with human immunodeficiency virus in Türkiye: a multicentre retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Predictors of mortality among individuals with advanced HIV disease in a contemporary Brazilian cohort.Revista panamericana de salud publica = Pan American journal of public health · 2026
    Article
  4. Article
  5. Article
  6. Predictors of mortality among individuals with advanced HIV disease in a contemporary Brazilian cohort.Revista panamericana de salud publica = Pan American journal of public health · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Impact ofFrontiers in immunology · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Getrud Joseph MollelIfakara Health Institute, Ifakara, Tanzania.
Lilian MoshiIfakara Health Institute, Ifakara, Tanzania.
Hoda HazemSwiss Tropical and Public Health Institute, Basel, Switzerland.
Anna EichenbergerIfakara Health Institute, Ifakara, Tanzania.
Olivia KitauIfakara Health Institute, Ifakara, Tanzania.
Herry MapesiIfakara Health Institute, Ifakara, Tanzania.
Tracy R GlassSwiss Tropical and Public Health Institute, Basel, Switzerland.
Daniel Henry ParisSwiss Tropical and Public Health Institute, Basel, Switzerland.
Maja WeisserIfakara Health Institute, Ifakara, Tanzania.
Fiona VanobberghenSwiss Tropical and Public Health Institute, Basel, Switzerland. fiona.vanobberghen@swisstph.ch.
University of Basel · CHSwiss Tropical and Public Health Institute · CHSt. Francis Referral Hospital · TZIfakara Health Institute · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNearly half of HIV-related deaths occur in East and Southern Africa, yet data on causes of death (COD) are scarce. We determined COD and associated factors among people living with HIV (PLHIV) in rural Tanzania.

methodsPLHIV attending the Chronic Diseases Clinic of Ifakara, Morogoro are invited to enrol in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO). Among adults (≥ 15 years) enrolled in 2005-2018, with follow-up through April 2019, we classified COD in comprehensive classes and as HIV- or non-HIV-related. In the subset of participants enrolled in 2013-2018 (when data were more complete), we assessed cause-specific mortality using cumulative incidences, and associated factors using proportional hazards models.

resultsAmong 9871 adults (65% female, 26% CD4 count < 100 cells/mm

conclusionIncidence of HIV-related mortality was higher than that of non-HIV-related mortality, even in more recent years, likely due to late presentation. Tuberculosis was the leading specific COD identified, particularly soon after enrolment, while in later calendar years cardiovascular and renal causes emerged as important, emphasising the need for improved screening and management.

Indexed as

HIV InfectionsAnti-Retroviral AgentsCause of DeathFemaleFollow-Up StudiesHumansMaleTanzaniaAnti-Retroviral AgentsCause of deathCohortHIV infectionsMortalityProportional hazards modelsTanzania

Identifiers

PMID34991496
PMCPMC8739638
OpenAlexW4205868269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.