Evidence map›Paper›PMID 34991416›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms.

Wagdy M Eldehna, Mohammed S Taghour, Tarfah Al-Warhi, Alessio Nocentini, Mostafa M Elbadawi, Hazem A Mahdy, Mohamed A Abdelrahman, Ohoud J Alotaibi, Nada Aljaeed, Diaaeldin M Elimam and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 6 countries.

Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Mohammed S TaghourPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Alessio NocentiniDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.ORCID 0000-0003-3342-702X
Mostafa M ElbadawiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Hazem A MahdyPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Mohamed A AbdelrahmanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt.
Ohoud J AlotaibiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Nada AljaeedDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Diaaeldin M ElimamDepartment of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Kamyar AfarinkiaInstitute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom.
Hatem A Abdel-AzizDepartment of Applied Organic Chemistry, National Research Center, Giza, Egypt.
Claudiu T SupuranDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.ORCID 0000-0003-4262-0323
Kafrelsheikh University · EGPrincess Nourah bint Abdulrahman University · SAAl-Azhar University · IDUniversity of Florence · ITEgyptian Russian University · EGUniversity of Bradford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different 2,4-thiazolidinedione-tethered coumarins

Indexed as

Drug DiscoveryAntigens, NeoplasmApoptosisCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesCell CycleCell ProliferationCell SurvivalCoumarinsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMCF-7 CellsMolecular StructureStructure-Activity Relationship2,4-thiazolidinedioneAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIICoumarinsThiazolidinediones3-acetylcoumarinanticancer agentsapoptosis inductionCarbonic anhydrase inhibitorshypoxic tumours

Identifiers

PMID34991416
PMCPMC8745369
OpenAlexW4206011470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.