ArticleClinical trials (London, England)2022
The representation of Indigenous peoples in chronic disease clinical trials in Australia, Canada, New Zealand, and the United States.
Article in Clinical trials (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Cardiovascular disease risk reduction interventions for indigenous women: an umbrella review.Health promotion international · 2026Pooled it
- Effectiveness of Digital Health Interventions on Body Weight and Dietary Intake Outcomes Among Culturally and Linguistically Diverse (CALD) and Indigenous Populations: A Systematic Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Strategies to promote the completion of patient-reported outcome measures by culturally and linguistically diverse and Indigenous Peoples in clinical care settings: A systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- Pooled it
- The sequential cohort randomized clinical trial: A study design for community-engaged clinical research in a rural American Indian community.Contemporary clinical trials · 2026Trial
- Strengthening Indigenous community engagement in clinical research: a formative evaluation in Northern British Columbia.BMJ global health · 2026Article
- Global landscape of kidney health across Indigenous populations.Nature reviews. Nephrology · 2026Review
- Inflammatory Bowel Disease in Indigenous Populations: A Scoping Review.Crohn's & colitis 360 · 2025Article
- An Australian perspective on clinical, economic and regulatory considerations in emerging nanoparticle therapies for infections.npj antimicrobials and resistance · 2025Review
- Article
- Health disparities and climate change in the Marshall Islands.Annals of medicine · 2024Article
- Physiology: A perspective from the Australian experience.Physiological reports · 2024Article
- Precision medicine in Australia: indigenous health professionals are needed to improve equity for Aboriginal and Torres Strait Islanders.International journal for equity in health · 2024Article
- Modifications of the readiness assessment for pragmatic trials tool for appropriate use with Indigenous populations.BMC medical research methodology · 2024Article
- COVID-19 infection and mortality among non-pregnant indigenous adults in Mexico 2020-2022: Impact of marginalisation.Journal of global health · 2023Article
- Recruitment, retention, and intervention adherence for a chronic illness self-management intervention with the Apsáalooke Nation.Public health review · 2022Article
- Reporting of health equity considerations in equity-relevant observational studies: Protocol for a systematic assessment.F1000Research · 2022Article
- Can Studying Genetically Predisposed Individuals Inform Prevention Strategies for RA?Healthcare (Basel, Switzerland) · 2021Article
- The Influence of Sociocultural Determinants on the Number of Diagnosed Chronic Illness Reported by Indigenous Peoples in Canada and the United States During SARS-CoV2.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIndigenous peoples are overrepresented with chronic health conditions and experience suboptimal outcomes compared with non-Indigenous peoples. Genetic variations influence therapeutic responses, thus there are potential risks and harm when extrapolating evidence from the general population to Indigenous peoples. Indigenous population-specific clinical studies, and inclusion of Indigenous peoples in general population clinical trials, are perceived to be rare. Our study (1) identified and characterized Indigenous population-specific chronic disease trials and (2) identified the representation of Indigenous peoples in general population chronic disease trials conducted in Australia, Canada, New Zealand, and the United States.
methodsFor Objective 1, publicly available clinical trial registries were searched from May 2010 to May 2020 using Indigenous population-specific terms and included for data extraction if in pre-specified chronic disease. For identified trials, we extracted Indigenous population group identity and characteristics, type of intervention, and funding type. For Objective 2, a random selection of 10% of registered clinical trials was performed and the proportion of Indigenous population participants enrolled extracted.
resultsIn total, 170 Indigenous population-specific chronic disease trials were identified. The clinical trials were predominantly behavioral interventions (n = 95). Among general population studies, 830 studies were randomly selected. When race was reported in studies (n = 526), Indigenous individuals were enrolled in 172 studies and constituted 5.6% of the total population enrolled in those studies.
conclusionClinical trials addressing chronic disease conditions in Indigenous populations are limited. It is crucial to ensure adequate representation of Indigenous peoples in clinical trials to ensure trial data are applicable to their clinical care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.