ArticleAnnals of pediatric endocrinology & metabolism2021
Balanced assessment of growth disorders using clinical, endocrinological, and genetic approaches.
Article in Annals of pediatric endocrinology & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Evaluation of growth hormone provocative tests in Egyptian children with growth hormone-related short stature.World journal of experimental medicine · 2026Article
- Commentary on "Genetic evaluation using next-generation sequencing of children with short stature: a single tertiary-center experience".Annals of pediatric endocrinology & metabolism · 2024Article
- Opportunities for digitally-enabled personalization and decision support for pediatric growth hormone therapy.Frontiers in endocrinology · 2024Review
- Key Stages in the Development and Establishment of Paediatric Endocrinology: A Template for Future Progress.Hormone research in paediatrics · 2024Review
- Relationship between short stature at 3 years old and height, weight, and body mass index changes for 6 years after birth: a retrospective, nationwide, population-based study of children born 2011-2014 in Korea.Annals of pediatric endocrinology & metabolism · 2023Article
- Central precocious puberty with hypothalamic hamartoma: the first case reports of 2 siblings with different phenotypes of Seckel syndrome 5.Annals of pediatric endocrinology & metabolism · 2023Article
- Commentary on "Growth plate extracellular matrix defects and short stature in children".Annals of pediatric endocrinology & metabolism · 2022Article
- Comprehensive genetic testing approaches as the basis for personalized management of growth disturbances: current status and perspectives.Endocrine connections · 2022Review
- Effect of educational intervention based on health belief model on mothers monitoring growth of 6-12 months child with growth disorders.BMC pediatrics · 2022Article
- The effects of growth hormone treatment on height in short children.Annals of pediatric endocrinology & metabolism · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the pathogenesis of pediatric growth disorders is often challenging. In many cases, no pathogenesis is identified, and a designation of idiopathic short stature is used. The investigation of short stature requires a combination of clinical, endocrinological, and genetic evaluation. The techniques used are described, with equal importance being given to each of the 3 approaches. Clinical skills are essential to elicit an accurate history, family pedigree, and symptoms of body system dysfunction. Endocrine assessment requires hormonal determination for the diagnosis of hormone deficiency and initiation of successful replacement therapy. Genetic analysis has added a new dimension to the investigation of short stature and now uses next-generation sequencing with a candidate gene approach to confirm probable recognizable monogenic disorders and exome sequencing for complex phenotypes of unknown origin. Using the 3 approaches of clinical, endocrine, and genetic probes with equal status in the hierarchy of investigational variables provides the clinician with the highest chance of identifying the correct causative pathogenetic mechanism in a child presenting with short stature of unknown origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.