Evidence map›Paper›PMID 34991253›Full record

ArticleEnvironment international2022

Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter.

Noel J Aquilina, Christopher M Havel, Roy M Harrison, Kin-Fai Ho, Neal L Benowitz, Peyton Jacob Iii

Open access · goldAbstract read
In one paragraph

Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Tobacco-specific and combustion pollutants in settled house dust in Malta.Journal of environmental exposure assessment · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Noel J AquilinaDepartment of Chemistry, University of Malta, Msida MSD 2080, Malta; Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA 94143, United States. Electronic address: noel.aquilina@um.edu.mt.
Christopher M HavelProgram in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA 94143, United States.
Roy M HarrisonDivision of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Kin-Fai HoThe Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Neal L BenowitzProgram in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA 94143, United States.
Peyton Jacob IiiProgram in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA 94143, United States.
University of California, San Francisco · USHong Kong Jockey Club · CNUniversity of Birmingham · GB

Funding

Research Support CoreP30DA012393 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON, JONES, REESE T. · 1999 to 2024
$17.1M
Liquid Chromatograph-Triple Quadrupole Mass SpectrometerS10RR026437 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON · 2010 to 2010
$448k
NCRR NIH HHS S10 RR026437NIDA NIH HHS P30 DA012393
6 · The paper itself

Abstract

The most important tobacco-specific nitrosamine found in cigarette smoke and formed in ageing smoke after cigarettes are extinguished is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). It is formed from nitrosation of nicotine, under particular conditions both in indoor and outdoor environments. NNK has been classified as a potent lung carcinogen which is expected to be found primarily in the particle-phase and to be stable in particulate matter. In this study tests have been carried out to show that a bisulfate-treated filter is more efficient than an untreated filter to collect both nicotine and NNK, and that the latter is stable in outdoor particulate matter. To characterize NNK in the outdoor environment, airborne samples were collected from 11 cities in USA, UK, Hong Kong and Malta with characteristics varying from low to high population densities and from urban to suburban to rural, and with desert characteristics and distinct climates. It has been shown that airborne particle + gas phase nicotine and particle-phase NNK behave in a linearly correlated manner. A seasonal analysis was carried out on a subset of data available from five sites in California, where the load of NNK in PM

Indexed as

NitrosaminesTobacco Smoke PollutionCarcinogensParticulate MatterSmokeTobacco Products4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCarcinogensNitrosaminesParticulate MatterSmokeTobacco Smoke PollutionNNKParticulate MatterTobacco SmokeTobacco-Specific Nitrosamines

Identifiers

PMID34991253
PMCPMC9056076
OpenAlexW3214868993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.