Evidence map›Paper›PMID 34991070›Full record

GuidelineJournal of the National Comprehensive Cancer Network : JNCCN2022

Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.

Robert J Motzer, Eric Jonasch, Neeraj Agarwal, Ajjai Alva, Michael Baine, Kathryn Beckermann, Maria I Carlo, Toni K Choueiri, Brian A Costello, Ithaar H Derweesh and 26 more

Registry-linked trialOpen access · greenAbstract readPractice Guideline
In one paragraph

Guideline in Journal of the National Comprehensive Cancer Network : JNCCN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07321197 (Template Lymph Node Dissection for Tumor Control in High-Risk Renal Cell Carcinoma), which is not on this map. Cited by 358 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
358citing papers in PubMed, 5 pooled it
94.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07321197 narecruitingnot on this mapstarted 2025, after this paper: background citation

Template Lymph Node Dissection for Tumor Control in High-Risk Renal Cell Carcinoma: A Prospective, Open-Label, Multicenter, Randomized Controlled Trial

TypeinterventionalSponsorTianjin Medical University Second HospitalRan2025 to 2033Enrolled220ConditionsRenal Cell Carcinoma (Kidney Cancer)ArmsTemplate Lymph Node Dissection, Selective Lymph Node Resection
3 · Its place in the literature

Who cites it

358 citing papers in PubMed, 5 syntheses or guidelines pooled it, 636 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Trial
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  9. Randomized phase II dose comparison LITESPARK-013 study of belzutifan in patients with advanced clear cell renal cell carcinoma.Annals of oncology : official journal of the European Society for Medical Oncology · 2024
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  11. Article
  12. Review
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298 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 3 countries.

Robert J MotzerMemorial Sloan Kettering Cancer Center.
Eric JonaschThe University of Texas MD Anderson Cancer Center.
Neeraj AgarwalHuntsman Cancer Institute at the University of Utah.
Ajjai AlvaUniversity of Michigan Rogel Cancer Center.
Michael BaineFred & Pamela Buffet Cancer Center.
Kathryn BeckermannVanderbilt-Ingram Cancer Center.
Maria I CarloMemorial Sloan Kettering Cancer Center.
Toni K ChoueiriDana-Farber/Brigham and Women's Cancer Center.
Brian A CostelloMayo Clinic Cancer Center.
Ithaar H DerweeshUC San Diego Moores Cancer Center.
Arpita DesaiUCSF Helen Diller Family Comprehensive Cancer Center.
Yasser GedThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
Saby GeorgeRoswell Park Comprehensive Cancer Center.
John L GoreFred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance.
Naomi HaasAbramson Cancer Center at the University of Pennsylvania.
Steven L HancockStanford Cancer Institute.
Payal KapurUT Southwestern Simmons Comprehensive Cancer Center.
Christos KyriakopoulosUniversity of Wisconsin Carbone Cancer Center.
Elaine T LamUniversity of Colorado Cancer Center.
Primo N LaraUC Davis Comprehensive Cancer Center.
Clayton LauCity of Hope National Medical Center.
Bryan LewisKidney Cancer Coalition.
David C MadoffYale Cancer Center/Smilow Cancer Hospital.
Brandon ManleyMoffitt Cancer Center.
M Dror MichaelsonMassachusetts General Hospital Cancer Center.
Amir MortazaviThe Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
Lakshminarayanan NandagopalO'Neal Comprehensive Cancer Center at UAB.
Elizabeth R PlimackFox Chase Cancer Center.
Lee PonskyCase Comprehensive Cancer Center/ University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute.
Sundhar RamalingamDuke Cancer Institute.
Brian ShuchUCLA Jonsson Comprehensive Cancer Center.
Zachary L SmithSiteman Cancer Center at Barnes- Jewish Hospital and Washington University School of Medicine.
Jeffrey SosmanRobert H. Lurie Comprehensive Cancer Center of Northwestern University.
Mary A DwyerNational Comprehensive Cancer Network.
Lisa A GurskiNational Comprehensive Cancer Network.
Angela MotterNational Comprehensive Cancer Network.
National Comprehensive Cancer NetworkMemorial Sloan Kettering Cancer Center · USBarnes-Jewish Hospital · USCancer Institute (WIA) · INCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZACity Of Hope National Medical Center · USDana-Farber Brigham Cancer Center · USDuke Cancer InstituteFox Chase Cancer Center · USMassachusetts General Hospital · USMoffitt Cancer Center · USMoores Cancer CenterRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityRoswell Park Comprehensive Cancer Center · USSidney Kimmel Comprehensive Cancer Center · USSmilow Cancer Hospital · USStanford Cancer InstituteSusan Thompson Buffett Foundation · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe University of Texas MD Anderson Cancer Center · US

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

The NCCN Guidelines for Kidney Cancer focus on the screening, diagnosis, staging, treatment, and management of renal cell carcinoma (RCC). Patients with relapsed or stage IV RCC typically undergo surgery and/or receive systemic therapy. Tumor histology and risk stratification of patients is important in therapy selection. The NCCN Guidelines for Kidney Cancer stratify treatment recommendations by histology; recommendations for first-line treatment of ccRCC are also stratified by risk group. To further guide management of advanced RCC, the NCCN Kidney Cancer Panel has categorized all systemic kidney cancer therapy regimens as "Preferred," "Other Recommended Regimens," or "Useful in Certain Circumstances." This categorization provides guidance on treatment selection by considering the efficacy, safety, evidence, and other factors that play a role in treatment selection. These factors include pre-existing comorbidities, nature of the disease, and in some cases consideration of access to agents. This article summarizes surgical and systemic therapy recommendations for patients with relapsed or stage IV RCC.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsHumansMedical Oncology

Identifiers

PMID34991070
PMCPMC10191161
OpenAlexW4205710681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.