Evidence map›Paper›PMID 34990770›Full record

ArticleBiochimie2022

Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity.

Swarna Bais, Abigail Norwillo, Gordon Ruthel, De'Broski R Herbert, Bruce D Freedman, Robert M Greenberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Swarna BaisDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA. Electronic address: sbais@upenn.edu.
Abigail NorwilloDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
Gordon RuthelDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
De'Broski R HerbertDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
Bruce D FreedmanDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
Robert M GreenbergDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
University of Pennsylvania · US

Funding

Physiological roles of schistosome TRP ion channels with atypical pharmacologyR01AI123173 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2017 to 2021
$2.0M
Myeloid derived IL-33 controls Treg responses during parasite infectionR01AI164715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2024
$1.6M
Discovery of novel antiparasitics that target a pharmacologically atypical schistosome Transient Receptor Potential (TRP) ion channelR21AI132912 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GREENBERG, ROBERT M · 2017 to 2018
$443k
Using transgenic parasitic nematodes to investigate Type 2 immunityR21AI144572 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R, LOK, JAMES B · 2019 to 2020
$443k
NIAID NIH HHS R01 AI123173NIAID NIH HHS R01 AI164715NIAID NIH HHS R21 AI132912NIAID NIH HHS R21 AI144572
6 · The paper itself

Abstract

Schistosomiasis is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma. Mono-therapeutic treatment of this disease with the drug praziquantel, presents challenges such as inactivity against immature worms and inability to prevent reinfection. Importantly, ion channels are important targets for many current anthelmintics. Transient receptor potential (TRP) channels are important mediators of sensory signals with marked effects on cellular functions and signaling pathways. TRPML channels are a class of Ca

Indexed as

AnthelminticsSchistosomiasis mansoniTransient Receptor Potential ChannelsAnimalsEndosomesPraziquantelSchistosoma mansoniAnthelminticsPraziquantelTransient Receptor Potential ChannelsLysosomesSchistosoma mansoniTegumentTRPML

Identifiers

PMID34990770
PMCPMC8950431
OpenAlexW4206190806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.