Evidence map›Paper›PMID 34990580›Full record

ArticleCell stem cell2022

Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome.

Fikri Birey, Min-Yin Li, Aaron Gordon, Mayuri V Thete, Alfredo M Valencia, Omer Revah, Anca M Paşca, Daniel H Geschwind, Sergiu P Paşca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 143 citations in OpenAlex.

  1. Biological psychiatry global open science · 2026
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  16. Parabiosis, Assembloids, Organoids (PAO).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fikri BireyDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Min-Yin LiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Aaron GordonProgram in Neurogenetics, Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Mayuri V TheteDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Alfredo M ValenciaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Omer RevahDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Anca M PaşcaDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pediatrics, Division of Neonatology, Stanford University, Stanford, CA 94305, USA.
Daniel H GeschwindProgram in Neurogenetics, Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Autism Research and Treatment, Semel Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute of Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sergiu P PaşcaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: spasca@stanford.edu.
Stanford Medicine · USUniversity of California, Los Angeles · US

Funding

Cross modal integration of molecular and physiological networks in ASD (2/2)U01MH115745 · NIMH · STANFORD UNIVERSITY · PI PASCA, SERGIU · 2017 to 2021
$4.0M
Role of L-type Calcium Channels in Human Interneuron Migration and IntegrationR01MH115012 · NIMH · STANFORD UNIVERSITY · PI PASCA, SERGIU · 2018 to 2022
$2.8M
Investigating the role of TCF4 in human interneuron function and dysfunctionK99MH119319 · NIMH · STANFORD UNIVERSITY · PI BIREY, FIKRI · 2019 to 2021
$203k
NIMH NIH HHS K99 MH119319NIMH NIH HHS R01 MH115012NIMH NIH HHS U01 MH115745
6 · The paper itself

Abstract

Defects in interneuron migration can disrupt the assembly of cortical circuits and lead to neuropsychiatric disease. Using forebrain assembloids derived by integration of cortical and ventral forebrain organoids, we have previously discovered a cortical interneuron migration defect in Timothy syndrome (TS), a severe neurodevelopmental disease caused by a mutation in the L-type calcium channel (LTCC) Ca

Indexed as

Autistic DisorderSyndactylyCell MovementCerebral CortexHumansInterneuronsLong QT SyndromeProsencephalonassembloidscalciumGABAinterneuronsorganoidsTimothy syndrome

Identifiers

PMID34990580
PMCPMC13492730
OpenAlexW4226056532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.