Evidence map›Paper›PMID 34990303›Full record

ArticleBioengineered2022

MicroRNA-128-3p suppresses interleukin-1β-stimulated cartilage degradation and chondrocyte apoptosis via targeting zinc finger E-box binding homeobox 1 in osteoarthritis.

Yu Sun, Xinnan Bao, Haiou Chen, Liping Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yu SunDepartment of Orthopectics, The First People's Hospital of Changzhou, Changzhou, P.R. China.
Xinnan BaoDepartment of Orthopectics, The First People's Hospital of Changzhou, Changzhou, P.R. China.
Haiou ChenDepartment of Orthopectics, The First People's Hospital of Changzhou, Changzhou, P.R. China.
Liping ZhouDepartment of Orthopectics, The First People's Hospital of Changzhou, Changzhou, P.R. China.ORCID 0000-0002-3777-1031
The First People's Hospital of Changzhou · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating studies have suggested that microRNAs (miRNAs) play vital roles in the pathogenesis of osteoarthritis (OA). Nevertheless, the specific function of miR-128-3p in OA remains unknown. In this study, we demonstrated that miR-128-3p was decreased and ZEB1 was increased in OA. Additionally, miR-128-3p expression was negatively correlated with ZEB1. miR-128-3p overexpression or ZEB1 silencing attenuated extracellular matrix degradation and cell apoptosis, and increased the proliferation of IL-1β-activated CHON-001 cells. Furthermore, ZEB1 was directly targeted by miR-128-3p. In addition, ZEB1 upregulation restored the effects of miR-128-3p overexpression on OA progression. Overall, our findings suggested that miR-128-3p might regulate the development of OA via targeting ZEB1.

Indexed as

AgedCell LineCell SurvivalChondrocytesExtracellular MatrixFemaleGene Expression RegulationHumansInterleukin-1betaMaleMicroRNAsMiddle AgedOsteoarthritisUp-RegulationZinc Finger E-box-Binding Homeobox 1Interleukin-1betaMicroRNAsMIRN128 microRNA, humanZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1apoptosisextracellular matrixMir-128-3posteoarthritisZEB1

Identifiers

PMID34990303
PMCPMC8805990
OpenAlexW4206110939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.