Evidence map›Paper›PMID 34990129›Full record

ArticleThe journal of physical chemistry. B2022

Modulation of the Directionality of Hole Transfer between the Base and the Sugar-Phosphate Backbone in DNA with the Number of Sulfur Atoms in the Phosphate Group.

Sergey A Denisov, Samuel Ward, Viacheslav Shcherbakov, Alexander D Stark, Renata Kaczmarek, Ewa Radzikowska-Cieciura, Dipra Debnath, Taisiya Jacobs, Anil Kumar, Michael D Sevilla and 4 more

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Sergey A DenisovInstitut de Chimie Physique, UMR 8000 CNRS/Université Paris-Saclay, Bât. 349, Orsay 91405 Cedex, France.ORCID 0000-0001-7881-1979
Samuel WardDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.
Viacheslav ShcherbakovInstitut de Chimie Physique, UMR 8000 CNRS/Université Paris-Saclay, Bât. 349, Orsay 91405 Cedex, France.
Alexander D StarkDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.
Renata KaczmarekCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Łódź 90-363, Poland.
Ewa Radzikowska-CieciuraCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Łódź 90-363, Poland.
Dipra DebnathDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.
Taisiya JacobsDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.
Anil KumarDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.ORCID 0000-0002-9979-7798
Michael D SevillaDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.ORCID 0000-0001-8799-5458
Pascal PernotInstitut de Chimie Physique, UMR 8000 CNRS/Université Paris-Saclay, Bât. 349, Orsay 91405 Cedex, France.ORCID 0000-0001-8586-6222
Roman DembinskiDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.
Mehran MostafaviInstitut de Chimie Physique, UMR 8000 CNRS/Université Paris-Saclay, Bât. 349, Orsay 91405 Cedex, France.ORCID 0000-0002-4510-8272
Amitava AdhikaryDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.ORCID 0000-0001-9024-9579
Oakland University · USCentre National de la Recherche Scientifique · FRCentrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk · PL

Funding

RADIOPROTECTION OF DNA BY THIOLS--OXYGEN AND LET EFFECTSR01CA045424 · NCI · OAKLAND UNIVERSITY · PI SEVILLA, MICHAEL DOUGLAS · 1987 to 2021
$4.2M
COBALT COMPLEXES OF MODIFIED NUCLEOSIDES, DINUCLEOSIDESR15CA111329 · NCI · OAKLAND UNIVERSITY · PI DEMBINSKI, ROMAN · 2005 to 2005
$217k
NCI NIH HHS R01 CA045424NCI NIH HHS R15 CA111329
6 · The paper itself

Abstract

This work shows that S atom substitution in phosphate controls the directionality of hole transfer processes between the base and sugar-phosphate backbone in DNA systems. The investigation combines synthesis, electron spin resonance (ESR) studies in supercooled homogeneous solution, pulse radiolysis in aqueous solution at ambient temperature, and density functional theory (DFT) calculations of in-house synthesized model compound dimethylphosphorothioate (DMTP(O

Indexed as

DNAPhosphatesPulse RadiolysisSugarsSulfurDNAPhosphatesSugarsSulfur

Identifiers

PMID34990129
PMCPMC8776618
OpenAlexW4206229300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.