Evidence map›Paper›PMID 34989851›Full record

ReviewCell and tissue research2023

Therapeutic strategies for identifying small molecules against prion diseases.

Elisa Uliassi, Lea Nikolic, Maria Laura Bolognesi, Giuseppe Legname

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Enhanced lysosomal activity prevents infection with PrPThe Journal of biological chemistry · 2026
    Article
  3. Review
  4. Review
  5. Therapeutic Trajectories in Human Prion Diseases.Sub-cellular biochemistry · 2025
    Review
  6. New Therapeutic Modalities in Prion Diseases.Sub-cellular biochemistry · 2025
    Review
  7. Adaptation of the protein misfolding cyclic amplification (PMCA) technique for the screening of anti-prion compounds.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  8. Review
  9. Review
  10. New developments in prion disease research.Cell and tissue research · 2023
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elisa UliassiDepartment of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, Bologna, Italy.ORCID http://orcid.org/0000-0002-0990-2532
Lea NikolicLaboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore Di Studi Avanzati (SISSA), Trieste, Italy.
Maria Laura BolognesiDepartment of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, Bologna, Italy. marialaura.bolognesi@unibo.it.
Giuseppe LegnameLaboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore Di Studi Avanzati (SISSA), Trieste, Italy. legname@sissa.it.ORCID http://orcid.org/0000-0003-0716-4393

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prion diseases are fatal neurodegenerative disorders, for which there are no effective therapeutic and diagnostic agents. The main pathological hallmark has been identified as conformational changes of the cellular isoform prion protein (PrP

Indexed as

Prion DiseasesPrionsDrug DiscoveryHumansLigandsPrion ProteinsLigandsPrion ProteinsPrionsIn silico screeningIn vitro screeningMulti-target-directed ligandsPrion diseasesTheranostics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.