ArticleEuropean radiology2022
Bone microarchitecture and metabolism in elderly male patients with signs of intravertebral cleft on MRI.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Incidence and Independent Risk Factors of Spinal Infection After Vertebral Augmentation: A Multicenter Propensity-Matched Case-Control Study.Neurospine · 2026Article
- A novel score system for imminent new vertebral fracture risk after vertebral augmentation: the predictive value of lumbar intervertebral disc degeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- An exploratory multimodal imaging and clinicopathological strategy for suspected Kümmell's disease in the absence of MRI.Frontiers in medicine · 2026Article
- Predictive factors associated with the onset of Kummell's disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Impact of intravertebral cleft types on percutaneous kyphoplasty outcomes in osteoporotic vertebral compression fractures.Scientific reports · 2025Article
- Article
- Expression and significance of cytokines in peripheral blood and bone microenvironment in Kummell's disease, osteoporotic vertebral compression fractures and nonosteoporotic patients.BMC musculoskeletal disorders · 2025Article
- Cemented vertebra and adjacent vertebra refractured in a chronic kidney disease-mineral and bone disorder patient: A case report.World journal of clinical cases · 2024Article
- Preoperative Prediction of New Vertebral Fractures after Vertebral Augmentation with a Radiomics Nomogram.Diagnostics (Basel, Switzerland) · 2023Article
- Oblique lateral interbody fusion combined with unilateral versus bilateral posterior fixation in patients with osteoporosis.Journal of orthopaedic surgery and research · 2023Article
- Magnetic Resonance Imaging Negative Spine Trauma Followed by a Delayed Intravertebral Vacuum Cleft-Kümmell's Disease: A Case Report and Literature Review.Orthopaedic surgery · 2023Review
- Biomechanical evaluation of a novel minimally invasive pedicle bone cement screw applied to the treatment of Kümmel's disease in porcine vertebrae.Frontiers in bioengineering and biotechnology · 2023Article
- A mid- and long-term follow-up study on the bilateral pedicle anchoring technique with percutaneous vertebroplasty for the treatment of Kümmell's disease.Frontiers in surgery · 2023Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIntravertebral cleft (IVC) is a common but not unique imaging manifestation in Kümmell's disease. To date, great controversy exists regarding the specific mechanisms of IVC. In this study, we aimed to investigate the characteristics of microarchitecture and metabolism in patients with IVC and to analyse the correlations between degree of vertebral collapse and risk factors.
methodsA total of 79 elderly men were included in this study. We divided all patients into two groups: the IVC group (30 patients) and the non-IVC group (49 patients). We compared the differences in microarchitecture and bone turnover marker (BTM) serum concentrations between the groups and analysed risk factors affecting vertebral collapse by using the Mann-Whitney U test and Spearman's correlation test.
resultsQuantitative analysis of the microarchitecture showed higher content of necrotic bone (p < 0.001) and lower content of lamellar bone (p < 0.001) in the IVC group. Analysis of BTMs identified lower concentration of N-terminal propeptide of type I collagen (PINP, p = 0.002) and higher concentration of β-isomerized C-terminal telopeptide (β-CTX, p < 0.001) in the IVC group. The correlation analysis showed that lamellar bone content (p < 0.001) and spine T-score (p = 0.011) were significantly correlated with the degree of vertebral collapse.
conclusionsIVC is a radiological feature of excessive bone resorption by higher activities of osteoclasts and decreased bone remodelling ability by lower activities of osteoblasts. Histomorphological feature in patients with IVC is delayed callus mineralisation, which may increase the risk of vertebral collapse. KEY POINTS: • A key histomorphological feature in patients with IVC is delayed callus mineralisation, which may aggravate the degree of vertebral collapse. • We investigated bone metabolism in patients with IVC to evaluate the activities of osteoclasts and osteoblasts directly. • We propose a novel hypothesis for the pathogenesis of IVC: bone resorption by higher activity of osteoclasts and decreased callus mineralisation ability by lower activity of osteoblasts are the main mechanisms leading to IVC.
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