Evidence map›Paper›PMID 34989833›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2022

Parkinson's disease patients with freezing of gait have more severe voice impairment than non-freezers during "ON state".

Qian Yu, Xiaoya Zou, Fengying Quan, Zhaoying Dong, Huimei Yin, Jinjing Liu, Hongzhou Zuo, Jiaman Xu, Yu Han, Dezhi Zou and 2 more

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Qian YuDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Xiaoya ZouDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Fengying QuanDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Zhaoying DongDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Huimei YinDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Jinjing LiuDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Hongzhou ZuoDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Jiaman XuDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Yu HanDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Dezhi ZouDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Yongming LiSchool of Microelectronics and Communication Engineering, Chongqing University, Chongqing, 400030, China.
Oumei ChengDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China. chengoumei01@aliyun.com.ORCID http://orcid.org/0000-0002-1889-6541
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNChongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpeech disorders and freezing of gait (FOG) in Parkinson's disease (PD) may have some common pathological mechanisms. The purpose of this study was to compare the acoustic parameters of PD patients with dopamine-responsive FOG (PD-FOG) and without FOG (PD-nFOG) during "ON state" and explore the ability of "ON state" voice features in distinguishing PD-FOG from PD-nFOG.

methodsA total of 120 subjects, including 40 PD patients with dopamine-responsive FOG, 40 PD-nFOG, and 40 healthy controls (HCs) were recruited. All subjects underwent neuropsychological tests. Speech samples were recorded through the sustained vowel pronunciation tasks during the "ON state" and then analyzed by the Praat software. A set of 27 voice features was extracted from each sample for comparison. Support vector machine (SVM) was used to build mathematical models to classify PD-FOG and PD-nFOG.

resultsCompared with PD-nFOG, the jitter, the standard deviation of fundamental frequency (F0SD), the standard deviation of pulse period (pulse period SD) and the noise-homophonic-ratio (NHR) were increased, and the maximum phonation time (MPT) was decreased in PD-FOG. The above voice features were correlated with the freezing of gait questionnaire (FOGQ). The average accuracy, specificity, and sensitivity of SVM models based on 27 voice features for classifying PD-FOG and PD-nFOG were 73.57%, 75.71%, and 71.43%, respectively.

conclusionsPD-FOG have more severe voice impairment than PD-nFOG during "ON state".

Indexed as

Gait Disorders, NeurologicParkinson DiseaseVoice DisordersDopamineGaitHumansDopamineAcoustic analysisFreezing of gaitParkinson’s diseaseVoice disorder

Identifiers

PMID34989833
OpenAlexW4205825010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.