ArticleApplied microbiology and biotechnology2022
Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota.
Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Potential of Dietary Microalgae as Feed Additive in Japanese Quail.Veterinary medicine international · 2026Review
- Exploring the Potential of Microalgae as Feed Ingredients for Sustainable Aquaculture: A Review of Nutritional and Environmental Benefits.Aquaculture nutrition · 2026Review
- DHA-Rich Algae Feed Modulates Atlantic Salmon Health, Microbiota and Stress Response.Aquaculture nutrition · 2026Article
- Dietary Spirulina (Animals : an open access journal from MDPI · 2025Article
- Impact of dietary composition on behavioural expression and gut microbiome dynamics in zebrafish.Pflugers Archiv : European journal of physiology · 2025Article
- The Potential Role of Microalgal Antioxidant Molecules on the Microbiota-Gut Axis in Inflammatory Bowel Diseases.Biomolecules · 2025Review
- Article
- Directly Measuring Atherogenic Lipoprotein Kinetics in Zebrafish With the Photoconvertible LipoTimer Reporter.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Oral Microalgae-Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microalgae: An Exciting Alternative Protein Source and Nutraceutical for the Poultry Sector.Food science of animal resources · 2025Review
- Article
- TransgenicMarine drugs · 2024Article
- Photobioreactors for building integration: A overview of designs and architectural potential.Heliyon · 2024Review
- Dietary supplementation with Dunaliella salina microalga promotes quail growth by altering lipid profile and immunity.Poultry science · 2024Article
- The Effect of Dietary Protein Hydrolysate from Black Soldier Fly Larvae and Schizochytrium on Palatability, Nutrient Metabolites and Health Status in Beagle Dogs.Metabolites · 2024Article
- Influence of a Mixture of Protein Hydrolysate from Black Soldier Fly Larvae and Schizochytrium on Palatability, Plasma Biochemistry, and Antioxidative and Anti-Inflammatory Capacity in Cat Diets.Animals : an open access journal from MDPI · 2024Article
- Dietary supplementation with a mixture of Dunaliella salina and Spirulina enhances broiler performance by improving growth, immunity, digestive enzymes and gut microbiota.Poultry science · 2024Article
- Lipid accumulation mechanism of Amphora coffeaeformis under nitrogen deprivation and its application as a feed additive in Carassius auratus aquaculture.Biotechnology for biofuels and bioproducts · 2023Article
- Microalgae-Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health.Global challenges (Hoboken, NJ) · 2023Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Microalgae are known to be abundant in various habitats around the globe, and are rich in high value-added products such as fatty acids, polysaccharides, proteins, and pigments. Microalgae can be exploited as the basic and primitive food source of aquatic animals. We investigated the effects of dietary supplementation with Schizochytrium sp., Spirulina platensis, Chloroella sorokiniana, Chromochloris zofingiensis, and Dunaliella salina on the growth performance, immune status, and intestinal health of zebrafish (Danio rerio). The results showed that these five microalgae diets could improve the feed conversion rate (FCR), especially the D. salina (FCR = 1.02%) and Schizochytrium sp. (FCR = 1.20%) additive groups. Moreover, the microalgae diets decreased the gene expression level of the pro-inflammatory cytokines IL6, IL8, and IL1β at a normal physiological state of the intestine, especially the Schizochytrium sp., S. platensis, and D. salina dietary groups. The expression of neutrophil marker b7r was increased in the C. sorokiniana diet group; after, the zebrafish were challenged with Vibrio anguillarum, improving the ability to resist this disease. We also found that microalgae diets could regulate the gut microbiota of fish as well as increase the relative abundance of probiotics. To further explain, Cetobacterium was significantly enriched in the S. platensis additive group and Stenotrophomonas was higher in the Schizochytrium sp. additive group than in the other groups. Conversely, harmful bacteria Mycoplasma reduced in all tested microalgae diet groups. Our study indicated that these microalgae could serve as a food source supplement and benefit the health of fish. KEY POINTS: • Microalgae diets enhanced the growth performance of zebrafish. • Microalgae diets attenuated the intestinal inflammatory responses of zebrafish. • Microalgae diets modulated the gut microbiota composition to improve fish health.
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