Evidence map›Paper›PMID 34989704›Full record

SynthesisPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2022

Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Lani Lieberman, Oliver Karam, Simon J Stanworth, Susan M Goobie, Gemma Crighton, Ruchika Goel, Jacques Lacroix, Marianne E Nellis, Robert I Parker, Katherine Steffen and 4 more

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Lani LiebermanDepartment of Clinical Pathology, University Health Network Hospitals; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.
Oliver KaramDivision of Pediatric Critical Care Medicine, Children's Hospital of Richmond at VCU, Richmond, VA.
Simon J StanworthNHS Blood and Transplant, Oxford University Hospitals NHS Foundation Trust, Radcliffe Department of Medicine and Oxford BRC Haematology Theme, University of Oxford, Oxford, United Kingdom.
Susan M GoobieDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Gemma CrightonDepartment of Haematology, Royal Children's Hospital, Melbourne, VIC, Australia.
Ruchika GoelDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, MD.
Jacques LacroixDivision of Pediatric Critical Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada.
Marianne E NellisDivision of Pediatric Critical Care Medicine, Department of Pediatrics, NY Presbyterian Hospital - Weill Cornell Medicine, New York, NY.
Robert I ParkerDepartment of Pediatric Hematology/Oncology, Renaissance School of Medicine, State University of New York at Stony Brook, Stony Brook, NY.
Katherine SteffenDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA.
Paul StrickerDepartment of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Stacey L ValentineDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA.
Marie E SteinerDivisions of Hematology and Critical Care, Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Boston Children's Hospital · USChildren's Hospital of Richmond at VCU · USJohns Hopkins University · USRoyal Children's Hospital · AUUniversité de Montréal · CAUniversity of Pennsylvania · USUniversity of Toronto · CA

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
TAXI-CAB: Transfusion and Anemia eXpert Initiative - Control/Avoidance of BleedingR13HL154544 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI NELLIS, MARIANNE · 2020 to 2020
$10k
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NHLBI NIH HHS R13 HL154544
6 · The paper itself

Abstract

objectivesTo present the consensus statements with supporting literature for plasma and platelet transfusions in critically ill neonates and children with malignancy, acute liver disease and/or following liver transplantation, and sepsis and/or disseminated intravascular coagulation from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

designSystematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children.

settingNot applicable. PATIENTS: Critically ill neonates and children with malignancy, acute liver disease and/or following liver transplantation, and sepsis and/or disseminated intravascular coagulation.

interventionsNone. MEASUREMENTS AND MAIN

resultsA panel of 13 experts developed evidence-based and, when evidence was insufficient, expert-based statements for plasma and platelet transfusions in critically ill neonates and children with malignancy, acute liver disease and/or following liver transplantation, and sepsis and/or disseminated intravascular coagulation. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed 12 expert consensus statements.

conclusionsIn the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding program, the current absence of evidence for use of plasma and/or platelet transfusion in critically ill children with malignancy, acute liver disease and/or following liver transplantation, and sepsis means that only expert consensus statements are possible for these areas of practice.

Indexed as

AnemiaDisseminated Intravascular CoagulationLiver Failure, AcuteLiver TransplantationNeoplasmsSepsisBlood Component TransfusionChildCritical CareCritical IllnessErythrocyte TransfusionEvidence-Based MedicineHemorrhageHumansInfant, NewbornPlasma

Identifiers

PMID34989704
PMCPMC8769367
OpenAlexW4206319700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.