Evidence map›Paper›PMID 34989676›Full record

ArticleeLife2022

Human monoclonal antibodies against

Lisanne de Vor, Bruce van Dijk, Kok van Kessel, Jeffrey S Kavanaugh, Carla de Haas, Piet C Aerts, Marco C Viveen, Edwin C Boel, Ad C Fluit, Jakub M Kwiecinski and 11 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 38 citations in OpenAlex.

  1. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. The Effects of Radioimmunotherapy and Antibiotics on Biofilm-Associated Implant Infections in a Preclinical Rat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024
    Review
  18. In Vivo Detection ofInternational journal of biomedical imaging · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Lisanne de Vor *Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.ORCID 0000-0002-2289-3378
Bruce van Dijk *Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands.
Kok van KesselDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Jeffrey S KavanaughDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States.
Carla de HaasDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Piet C AertsDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Marco C ViveenDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Edwin C BoelDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.ORCID 0000-0002-8506-0357
Ad C FluitDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Jakub M KwiecinskiDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States.ORCID 0000-0001-9472-2896
Gerard C KrijgerDepartment of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, Netherlands.
Ruud M RamakersMILabs B.V, Utrecht, Netherlands.
Freek J BeekmanMILabs B.V, Utrecht, Netherlands.
Ekaterina DadachovaCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.ORCID 0000-0001-7300-6479
Marnix Geh LamDepartment of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, Netherlands.
H Charles VogelyDepartment of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands.
Bart Ch van der WalDepartment of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands.
Jos Ag van StrijpDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States.
Harrie WeinansDepartment of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands.
Suzan Hm RooijakkersDepartment of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.ORCID 0000-0003-4102-0377
University Medical Center Utrecht · NLUniversity Medical Center · USUniversity of Colorado Denver · USUniversity of Saskatchewan · CAVA Eastern Colorado Health Care System · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
–
BLRD VA I01 BX002711NIAID NIH HHS P01 AI083211
6 · The paper itself

Abstract

Implant-associated

Indexed as

BiofilmsAnimalsAntibodies, MonoclonalCatheter-Related InfectionsHumansMaleMiceMice, Inbred BALB CStaphylococcal InfectionsStaphylococcus aureusTeichoic AcidsAntibodies, MonoclonalTeichoic Acidsbiofilminfectious diseasemicrobiologymonoclonal antibodiesStaphylococcus aureus

Identifiers

PMID34989676
PMCPMC8751199
OpenAlexW4205246021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.