Evidence map›Paper›PMID 34989638›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2022

Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits.

George P Philipopoulos, John Tat, Adriano Chan, Jingjing Jiang, David Mukai, Tanya Burney, Melody Doosty, Sari Mahon, Hemal H Patel, Carl W White and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The vitamin BClinical toxicology (Philadelphia, Pa.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

George P PhilipopoulosBeckman Laser Institute, University of California, Irvine, CA, USA.
John TatDepartment of Medicine, University of California, San Diego, CA, USA.
Adriano ChanDepartment of Medicine, University of California, San Diego, CA, USA.
Jingjing JiangDepartment of Medicine, University of California, San Diego, CA, USA.
David MukaiBeckman Laser Institute, University of California, Irvine, CA, USA.
Tanya BurneyBeckman Laser Institute, University of California, Irvine, CA, USA.
Melody DoostyBeckman Laser Institute, University of California, Irvine, CA, USA.
Sari MahonBeckman Laser Institute, University of California, Irvine, CA, USA.
Hemal H PatelVA San Diego Healthcare System and Department of Anesthesiology, University of California, San Diego, CA, USA.
Carl W WhiteDepartment of Pediatrics, University of Colorado, Aurora, CO, USA.
Matthew BrennerBeckman Laser Institute, University of California, Irvine, CA, USA.
Jangwoen LeeBeckman Laser Institute, University of California, Irvine, CA, USA.
Gerry R BossDepartment of Medicine, University of California, San Diego, CA, USA.
Beckman Laser Institute and Medical Clinic · USUniversity of California, San Diego · USUniversity of California, Irvine · USUniversity of Colorado Denver · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Thiols in sulfur mustard toxicityU54ES015678 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI WHITE, CARL W · 2006 to 2015
$20.5M
Photonics Monitoring and Modeling CoreU54ES027698 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI WHITE, CARL W · 2016 to 2021
$16.7M
Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide AntidoteU01NS087964 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2015 to 2019
$4.3M
NIEHS NIH HHS U54 ES015678NIEHS NIH HHS U54 ES027698NIGMS NIH HHS K12 GM068524NINDS NIH HHS U01 NS087964
6 · The paper itself

Abstract

contextMethyl mercaptan (CH

resultsWe found that cobinamide binds to CH

conclusionWe conclude that cobinamide could potentially serve as a CH

Indexed as

AntidotesCobamidesAnimalsChlorocebus aethiopsHumansMiceRabbitsSulfhydryl CompoundsVitamin B 12AntidotesCobamidescobinamideSulfhydryl CompoundsVitamin B 12cobinamideMethyl mercaptanrescue

Identifiers

PMID34989638
PMCPMC9662850
OpenAlexW4206773011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.