Evidence map›Paper›PMID 34989322›Full record

ArticleCell cycle (Georgetown, Tex.)2022

Esco2 and cohesin regulate CRL4 ubiquitin ligase

Annie C Sanchez, Elise D Thren, M Kathryn Iovine, Robert V Skibbens

Open access · hybridAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Retinoic Acid InfluencesBioelectricity · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Annie C SanchezDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, USA.
Elise D ThrenDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, USA.
M Kathryn IovineDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0003-0046-8482
Robert V SkibbensDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0003-4216-8306
Lehigh University · US

Funding

DNA helicase functions in genome maintenanceR15GM110631 · NIGMS · LEHIGH UNIVERSITY · PI SKIBBENS, ROBERT · 2014 to 2017
$803k
Novel targets of the Roberts Syndrome acetyltransferase Esco2/Eco1R15GM139097 · NIGMS · LEHIGH UNIVERSITY · PI SKIBBENS, ROBERT · 2020 to 2020
$469k
Novel targets of CRL4 ligase within Cohesinopathy pathwaysR03HD107169 · NICHD · LEHIGH UNIVERSITY · PI SKIBBENS, ROBERT · 2022 to 2023
$157k
NICHD NIH HHS R03 HD107169NIGMS NIH HHS R15 GM110631NIGMS NIH HHS R15 GM139097
6 · The paper itself

Abstract

Cornelia de Lange syndrome (CdLS) and Roberts syndrome (RBS) are severe developmental maladies that arise from mutation of cohesin (including

Indexed as

De Lange SyndromeThalidomideAcetyltransferasesCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsCraniofacial AbnormalitiesDNA-Binding ProteinsEctromeliaHumansHypertelorismLigasesMutationReceptors, Interleukin-17UbiquitinUbiquitin-Protein LigasesAcetyltransferasesCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsDDB1 protein, humanDNA-Binding ProteinsESCO2 protein, humanIL17RB protein, humanLigasesReceptors, Interleukin-17ThalidomideUbiquitinUbiquitin-Protein Ligasesbirth defectscohesinopathiescornelia de lange syndrome (Cdls)CRL4 ubiquitin ligaseRoberts syndrome (RBS)thalidomide

Identifiers

PMID34989322
PMCPMC8942496
OpenAlexW4225981828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.