Evidence map›Paper›PMID 34989321›Full record

ArticleGut microbes

Interleukin-1β secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair.

Wan-Jung H Wu, Myunghoo Kim, Lin-Chun Chang, Adrien Assie, Fatima B Saldana-Morales, Daniel F Zegarra-Ruiz, Kendra Norwood, Buck S Samuel, Gretchen E Diehl

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 56 citations in OpenAlex.

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  20. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Wan-Jung H WuImmunology Graduate Program, Baylor College of Medicine, Houston, TX, USA.
Myunghoo KimDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Lin-Chun ChangMemorial Sloan Kettering Cancer Center, Immunology Program of the Sloan Kettering Institute, New York, NY, USA.
Adrien AssieDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Fatima B Saldana-MoralesMemorial Sloan Kettering Cancer Center, Immunology Program of the Sloan Kettering Institute, New York, NY, USA.ORCID 0000-0001-5192-5722
Daniel F Zegarra-RuizMemorial Sloan Kettering Cancer Center, Immunology Program of the Sloan Kettering Institute, New York, NY, USA.ORCID 0000-0003-0752-7238
Kendra NorwoodDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Buck S SamuelDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Gretchen E DiehlMemorial Sloan Kettering Cancer Center, Immunology Program of the Sloan Kettering Institute, New York, NY, USA.ORCID 0000-0002-1841-2842
Memorial Sloan Kettering Cancer Center · USBaylor College of Medicine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Orchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions R01AI125264 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI GRETCHEN E DIEHL · 2017 to 2026
$4.1M
Microbial programming of host physiologyDP2DK116645 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SAMUEL, BUCK SPARROW · 2017 to 2017
$2.4M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Commensal-dependent induction of protective immunityR21AI123945 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI DIEHL, GRETCHEN E · 2017 to 2018
$391k
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIAID NIH HHS R01 AI125264NIAID NIH HHS R21 AI123945NIDDK NIH HHS DP2 DK116645NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

The gut microbiota is essential for maintenance and repair of the intestinal epithelial barrier. As shifts in both intestinal epithelial barrier function and microbiota composition are found in inflammatory bowel disease patients, it is critical to understand the role of distinct bacteria in regulating barrier repair. We identified a mouse commensal

Indexed as

Gastrointestinal MicrobiomeSymbiosisAnimalsBacteriaBacterial Physiological PhenomenaColitisHumansInterleukin-18Interleukin-1betaIntestinal MucosaMacrophagesMiceMice, Inbred C57BLInterleukin-18Interleukin-1betacolitisCX3CR1+ MNPSIL-1βIL-22ILC3sintestinal barrier repairMicrobiota

Identifiers

PMID34989321
PMCPMC8741296
OpenAlexW4205581309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.