Evidence map›Paper›PMID 34989167›Full record

ArticleESC heart failure2022

CA-125 variation in acute heart failure: a single-centre analysis.

Patrícia Lourenço, Filipe M Cunha, Catarina Elias, Catarina Fernandes, Isaac Barroso, João T Guimarães, Paulo Bettencourt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Patrícia LourençoInternal Medicine Department, Centro Hospitalar e Universitário São João, Porto, Portugal.ORCID 0000-0003-1076-4031
Filipe M CunhaEndocrinology Department, Centro Hospitalar do Tâmega e Sousa, Porto, Portugal.
Catarina EliasInternal Medicine Department, Centro Hospitalar e Universitário São João, Porto, Portugal.
Catarina FernandesInternal Medicine Department, Hospital CUF Porto, Porto, Portugal.
Isaac BarrosoClinical Pathology Department, Centro Hospitalar e Universitário São João, Porto, Portugal.
João T GuimarãesMedicine Faculty, Porto University, Porto, Portugal.
Paulo BettencourtMedicine Faculty, Porto University, Porto, Portugal.
Universidade do Porto · PTHospital de São João · PTCentro Hospitalar do Tâmega e Sousa · PTCUF Porto Hospital · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsA decrease in carbohydrate antigen 125 (CA-125) predicts survival advantage in chronic heart failure (HF); the impact of its variation in acute HF is unknown. We studied the association of CA-125 decrease with prognosis in acute HF. METHODS AND

resultsWe studied acute hospitalized HF patients. Predictors of admission and discharge CA-125 were determined by linear regression. Follow-up was 1 year; endpoint was all-cause death. The association of admission and discharge CA-125 with mortality was assessed using a Cox-regression analysis. A Cox-regression analysis was also used to assess the prognostic impact of CA-125 decrease during hospitalization. Analysis was stratified by length of hospital stay (LOS). We studied 363 patients, 51.5% male, mean age 75 ± 12 years, 51.5% ischaemic, 30.0% with preserved ejection fraction, and 57.3% with reduced ejection fraction; patients presented elevated comorbidity burden. Median LOS was 7 (5-11) days. In the subgroup of 262 patients with CA-125 measured both at admission and at discharge, we reported a significant increase in its levels: 56.0 (26.0-160.7) U/mL to 74.0 (32.3-195.0) U/mL. Independent predictors of admission CA-125 were higher BNP and lower creatinine. Predictors of discharge CA-125 were higher discharge BNP, lower discharge albumin, and younger age. Both admission and discharge CA-125 predicted mortality. During follow-up, 75 (31.8%) patients died. A decrease in CA-125 predicted a 68% reduction in the 1 year death risk only in patients with LOS > 10 days.

conclusionsOur results suggest that an early re-evaluation (>10 days) with CA-125 measurement after an acute HF hospitalization may be of interest in patient management.

Indexed as

Heart FailureAgedAged, 80 and overFemaleHospitalizationHumansMaleMiddle AgedPatient DischargePrognosisStroke VolumeAcute heart failureBiomarkersCA-125Prognosis

Identifiers

PMID34989167
PMCPMC8934914
OpenAlexW4206386463

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.