Evidence map›Paper›PMID 34989151›Full record

ArticleClinical and experimental dental research2022

Gender and risk-taking behaviors influence the clinical presentation of oral squamous cell carcinoma.

Susanne Wolfer, Annika Kunzler, Tatjana Foos, Cornelia Ernst, Andreas Leha, Stefan Schultze-Mosgau

Open access · goldAbstract read
In one paragraph

Article in Clinical and experimental dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Microorganisms · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Prognostic factors of oral squamous cell carcinoma: a five-year retrospective study in Cluj-Napoca, Romania.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Susanne WolferDepartment of Oral and Maxillofacial & Plastic Surgery, Jena University Hospital, Jena, Germany.ORCID 0000-0002-4134-2301
Annika KunzlerDepartment of Oral and Maxillofacial & Plastic Surgery, Jena University Hospital, Jena, Germany.
Tatjana FoosDepartment of Oral and Maxillofacial & Plastic Surgery, Jena University Hospital, Jena, Germany.
Cornelia ErnstDepartment of Oral and Maxillofacial & Plastic Surgery, Jena University Hospital, Jena, Germany.
Andreas LehaDepartment of Medical Statistics, University Medical Center Goettingen, Goettingen, Germany.
Stefan Schultze-MosgauDepartment of Oral and Maxillofacial & Plastic Surgery, Jena University Hospital, Jena, Germany.
Jena University Hospital · DE

Funding

None
6 · The paper itself

Abstract

objectiveThe common risk factors for oral squamous cell carcinoma (OSCC) are smoking and alcohol abuse. A small percentage of patients, mostly women, are demonstrating oral cancer without the common risk behavior. This study investigates how gender and different patterns of lifestyle factors influence the clinical presentation of OSCC. PATIENTS AND

methodsFrom this retrospective study, demographical and tumor-specific data and lifestyle factors were analyzed. Statistical analyses were performed using the χ

resultsAmong a total of 308 patients, men represented the majority of smokers (87.2%) and the female cohort were largely non-smokers and non-drinkers (64.9%). For age, tumor site and N-stage it looks like that differences of men and women are driven by the different risk behavior. But if the lifestyle factors are taken into account, we observe contrary effects between men and women for T-, N-, and UICC-stage. For different cancer locations we saw opposite effects with gender and risk profile. These effects are not dose-dependent explainable for gender.

conclusionSome but not all differences in the development of OSCC for men and women are explainable by the respective difference in lifestyle behavior. Some further investigations are necessary to find explanations for the obvious differences between men and women in developing OSCC.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsFemaleHumansMaleRetrospective StudiesRisk-TakingSquamous Cell Carcinoma of Head and Neckalcoholgenderoral squamous cell carcinomasmoking

Identifiers

PMID34989151
PMCPMC8874093
OpenAlexW4206714375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.