ArticleThe European journal of neuroscience2022
Individual differences in threat and reward neural circuitry activation: Testing dimensional models of early adversity, anxiety and depression.
Article in The European journal of neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related disorders.Molecular psychiatry · 2026Article
- A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.Brain, behavior, & immunity - health · 2026Article
- Cognitive and affective neurodevelopment in youth exposed to deprivation and threat.bioRxiv : the preprint server for biology · 2026Article
- Differential associations of childhood abuse and neglect with neural responses to social reward and punishment in adults with anxiety or depression.Translational psychiatry · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- The neurobiological effects of childhood maltreatment on brain structure, function, and attachment.European archives of psychiatry and clinical neuroscience · 2025Review
- Differential Associations of Childhood Abuse and Neglect with Neural Responses to Social Reward and Punishment in Adults with Anxiety or Depression.Research square · 2025Article
- Heightened subcortical reactivity to uncertain-threat is associated with future internalizing symptoms, conditional on stress exposure.bioRxiv : the preprint server for biology · 2025Article
- Comparing the multivariate relationships of conceptual adversity models and structural brain development in adolescent girls: A registered report.Developmental psychology · 2024Article
- Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence.Behavioural brain research · 2024Article
- Psychological risk factors and cardiovascular disease.Frontiers in psychology · 2024Review
- Association between reward-related functional connectivity and tri-level mood and anxiety symptoms.NeuroImage. Clinical · 2023Article
- Individual differences in threat and reward neural circuitry activation: Testing dimensional models of early adversity, anxiety and depression.The European journal of neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Altered functioning of the brain's threat and reward circuitry has been linked to early life adversity and to symptoms of anxiety and depression. To date, however, these relationships have been studied largely in isolation and in categorical-based approaches. It is unclear to what extent early life adversity and psychopathology have unique effects on brain functioning during threat and reward processing. We examined functional brain activity during a face processing task in threat (amygdala and ventromedial prefrontal cortex) and reward (ventral striatum and orbitofrontal cortex) regions of interest among a sample (N = 103) of young adults (aged 18-19 years) in relation to dimensional measures of early life adversity and symptoms of anxiety and depression. Results demonstrated a significant association between higher scores on the deprivation adversity dimension and greater activation of reward neural circuitry during viewing of happy faces, with the largest effect sizes observed in the orbitofrontal cortex. We found no significant associations between the threat adversity dimension, or symptom dimensions of anxiety and depression, and neural activation in threat or reward circuitries. These results lend partial support to theories of adversity-related alterations in neural activation and highlight the importance of testing dimensional models of adversity and psychopathology in large sample sizes to further our understanding of the biological processes implicated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.