Evidence map›Paper›PMID 34988972›Full record

ArticleJournal of the American Geriatrics Society2022

The impact of weight change and measures of physical functioning on mortality.

Lisa J Underland, Peter F Schnatz, Robert A Wild, Nazmus Saquib, Aladdin H Shadyab, Matthew Allison, Hailey Banack, Sylvia Wassertheil-Smoller

Abstract read
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In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lisa J UnderlandDepartment of Pediatric Endocrinology and Diabetes, Children's Hospital at Montefiore, Bronx, New York, USA.
Peter F SchnatzDepartment of Obstetrics/Gynecology and Internal Medicine, Reading Hospital/Tower Health, West Reading, Pennsylvania, USA.
Robert A WildDepartment of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Nazmus SaquibDepartment of Clinical Sciences, College of Medicine, Sulaiman Alrajhi University, Al Bukayriyah, Saudi Arabia.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego School of Medicine, San Diego, California, USA.
Matthew AllisonDepartment of Family Medicine, University of Southern California, San Diego, California, USA.
Hailey BanackDepartment of Epidemiology and Environmental Health, University of Buffalo, Buffalo, New York, USA.
Sylvia Wassertheil-SmollerDepartment of Epidemiology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-5447-4653

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY E. PESSIN · 2015 to 2026
$27.7M
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIDDK NIH HHS P30 DK020541NIH HHSU.S. Department of Health and Human Services
6 · The paper itself

Abstract

introductionLower grip strength and measures of physical functioning are associated with all-cause mortality. Relationships among long-term weight loss, physical functioning, and mortality in older women are understudied.

methodsParticipants were 5039 women who were part of the Long Life Study (LLS) ancillary study to the Woman's Health Initiative (WHI). Average age was 78.76 ± 6.92. We defined long-term weight loss or gain as a decrease or increase of 5% or more of baseline body weight. Our primary outcome was all-cause mortality and our secondary outcomes were vascular death, and coronary heart disease (CHD). The mean follow-up time was 5.4 years. Cox regression modeling was performed for each outcome of interest. Variables of interest were weight change, grip strength, and functional status as measured by the Short Physical Performance Battery (SPPB) controlling for multiple potential confounders.

resultsWeight loss of 5% or more percent body weight was associated with a hazard ratio of 1.66 (1.37-2.01) for all-cause mortality. Weight gain was not related to mortality or cardiovascular outcomes. Those in the highest grip strength quartile had a hazard ratio of 0.51 (0.39-0.66) for all-cause mortality. For the SPPB the hazard ratio was 0.29 (0.21-0.40), adjusting for changes in weight, race, smoking, history CHD, smoking, and diabetes. Higher grip strength and SPPB were associated with lower risks for vascular death, and CHD, independently of weight change.

conclusionsWeight loss was associated with increased mortality. Stronger grip strength and higher SPPB scores were associated with lower mortality risk independent of weight change.

Indexed as

Coronary DiseaseDiabetes MellitusAgedAged, 80 and overFemaleHand StrengthHumansProportional Hazards ModelsWeight Lossmortalityobesityweight change

Identifiers

PMID34988972
PMCPMC8986581

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.