ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2022
A putative PCV3-associated disease in piglets from Southern Brazil.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.Veterinary pathology · 2026Article
- Development of a Highly Specific Monoclonal Antibody-Based Sandwich ELISA for Rapid Detection of Porcine Circovirus Type 3.Viruses · 2025Article
- Evaluation of the infectivity of three porcine reproductive and respiratory syndrome virus (PRRSV) variants.Veterinary research · 2025Article
- Detection Rate of Porcine Circoviruses in Different Ages and Production Herds of Intensive Pig Farms in China.Animals : an open access journal from MDPI · 2025Article
- A case report of porcine circovirus 3 (PCV3) reproductive disease in Iberian semi-outdoor reared sows.Porcine health management · 2024Article
- Retrospective investigation of porcine circoviruses in cases of porcine dermatitis and nephropathy syndrome.Veterinary research · 2024Article
- Article
- Main Causes of Death in Piglets from Different Brazilian Nursery Farms Based on Clinical, Microbiological, and Pathological Aspects.Animals : an open access journal from MDPI · 2023Article
- Recombinant Orf virus induced antibody production against capsid protein of porcine circovirus type 3 in mice.Veterinary research communications · 2023Article
- Molecular detection of porcine circovirus (PCV2 and PCV3), torque teno swine virus 1 and 2 (TTSuV1 and TTSuVk2), and histopathological findings in swine organs submitted to regular slaughter in Southeast, Brazil.Brazilian journal of veterinary medicine · 2023Article
- Porcine circovirus type 3: immunohistochemical detection in lesions of naturally affected piglets.Frontiers in veterinary science · 2023Article
- Experimental Inoculation of Porcine Circovirus 3 (PCV-3) in Pregnant Gilts Causes PCV-3-Associated Lesions in Newborn Piglets that Persist until Weaning.Transboundary and emerging diseases · 2023Article
- High Prevalence of Porcine Circovirus 3 in Hungarian Pig Herds: Results of a Systematic Sampling Protocol.Viruses · 2022Article
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Authors and funding
11 authors.
Funding
Abstract
Porcine circovirus type 3 (PCV3) is widely distributed worldwide, and its association with clinical disease in pigs has been studied in recent years. This study describes a novel PCV3-associated clinical disease in piglets from Brazil. Since September 2020, we received 48 piglets with large caudally rotated ears, weakness, and dyspnea. Most piglets were from gilts and died 1-5 days after birth. Two piglets that presented similar clinical signs and survived until 35-60 days had a marked decrease in growth rate. At post-mortem examination, the lungs did not collapse due to marked interlobular edema. Microscopically, the main feature was multisystemic vasculitis characterized by lymphocytes and plasma cells infiltrating and disrupting the wall of vessels, lymphohistiocytic interstitial pneumonia, myocarditis, and encephalitis. Viral replication was confirmed in these lesions through in situ hybridization (ISH-RNA). Seventeen cases were positive for PCV3 in PCR analysis, and all samples tested negative for porcine circovirus (PCV1, and PCV2); porcine parvovirus (PPV1, 2, 5, and 6); atypical porcine pestivirus (APPV); porcine reproductive and respiratory syndrome (PRRSV); and ovine herpesvirus-2 (OvHV-2). Phylogenetic analysis of the ORF2 sequence from five different pig farms showed that the PCV3a clade is circulating among Brazil's swineherds and causing neonatal piglet losses. This is the first report of PCV3a-associated disease in neonatal pigs from farms in Brazil.
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