Evidence map›Paper›PMID 34988871›Full record

ArticleTranslational stroke research2022

Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol.

Ben Gaastra, Sheila Alexander, Mark K Bakker, Hemant Bhagat, Philippe Bijlenga, Spiros Blackburn, Malie K Collins, Sylvain Doré, Christoph Griessenauer, Philipp Hendrix and 15 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05526352 (@neurIST), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05526352 recruitingnot on this map

@neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux

Typeobservational_patient_registrySponsorUniversity Hospital, GenevaRan2015 to 2040Enrolled20,000ConditionsIntracranial Aneurysm
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ben GaastraClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.ORCID http://orcid.org/0000-0002-7517-6882
Sheila AlexanderSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, 15261, USA.ORCID http://orcid.org/0000-0001-5866-027X
Mark K BakkerDepartment of Neurology, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Heidelberlaan 100, 3584, CX, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-7887-9014
Hemant BhagatDivision of Neuroanaesthesia, Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.ORCID http://orcid.org/0000-0001-9200-9915
Philippe BijlengaNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-3586-2757
Spiros BlackburnUniversity of Texas Houston Health Science Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-2902-5079
Malie K CollinsGeisinger Commonwealth School of Medicine, Scranton, PA, USA.ORCID http://orcid.org/0000-0002-9553-3824
Sylvain DoréDepartments of Anesthesiology, Neurology, Psychiatry, Pharmaceutics, and Neuroscience, College of Medicine, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-3771-5109
Christoph GriessenauerDepartment of Neurosurgery, Geisinger, Danville, PA, USA.ORCID http://orcid.org/0000-0002-2952-3812
Philipp HendrixDepartment of Neurosurgery, Geisinger, Danville, PA, USA.ORCID http://orcid.org/0000-0003-0017-5049
Eun Pyo HongInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, South Korea.ORCID http://orcid.org/0000-0001-7789-686X
Isabel C HostettlerStroke Research Centre, University College London, Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-9004-2540
Henry HouldenStroke Research Centre, University College London, Institute of Neurology, London, UK.
Koji IIharaNational Cerebral and Cardiovascular Center Hospital, 6-1 Kishibe-Shimmachi, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0002-7852-220X
Jin Pyeong JeonInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, South Korea.ORCID http://orcid.org/0000-0001-8543-6855
Bong Jun KimInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, South Korea.ORCID http://orcid.org/0000-0003-3374-5554
Munish KumarDivision of Neuroanaesthesia, Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.ORCID http://orcid.org/0000-0002-9588-0615
Sandrine MorelNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-1538-3553
Paul NyquistDepartments of Neurology, Anesthesia/Critical Care Medicine, Neurosurgery and General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0001-6078-3543
Dianxu RenSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, 15261, USA.ORCID http://orcid.org/0000-0002-1160-8922
Ynte M RuigrokDepartment of Neurology, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Heidelberlaan 100, 3584, CX, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-5396-2989
David WerringStroke Research Centre, University College London, Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-2074-1861
Ian Galea *Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK. i.galea@soton.ac.uk.ORCID http://orcid.org/0000-0002-1268-5102
Diederik Bulters *Department of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton, Southampton, SO16 6YD, UK.ORCID http://orcid.org/0000-0001-9884-9050
Will Tapper *Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.ORCID http://orcid.org/0000-0002-5896-1889

Funding

Role of 20-HETE on Vasospasm-Induced Ischemia after Subarachnoid HemorrhageR01NR004339 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLOYAC, SAMUEL M, SHERWOOD, PAULA R · 1999 to 2013
$7.2M
Role of Haptoglobin Genotype on Neuroinflammation and Coagulation Following Aneurysmal Subarachnoid HemorrhageK23NS106054 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLACKBURN, SPIROS · 2018 to 2022
$875k
Testing brain penetrant iron chelators and investigating putative clearance pathway in ICHR56NS116076 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2020 to 2020
$381k
Department of HealthEuropean Research Council PRYSM, grant agreement No. 852173NIH HHS K23NS106054NINDS NIH HHS K23 NS106054NINDS NIH HHS R56 NS116076NINR NIH HHS R01 NR004339NINR NIH HHS R01NR004339Swiss National Science Foundation NA
6 · The paper itself

Abstract

Aneurysmal subarachnoid haemorrhage (aSAH) results in persistent clinical deficits which prevent survivors from returning to normal daily functioning. Only a small fraction of the variation in clinical outcome following aSAH is explained by known clinical, demographic and imaging variables; meaning additional unknown factors must play a key role in clinical outcome. There is a growing body of evidence that genetic variation is important in determining outcome following aSAH. Understanding genetic determinants of outcome will help to improve prognostic modelling, stratify patients in clinical trials and target novel strategies to treat this devastating disease. This protocol details a two-stage genome-wide association study to identify susceptibility loci for clinical outcome after aSAH using individual patient-level data from multiple international cohorts. Clinical outcome will be assessed using the modified Rankin Scale or Glasgow Outcome Scale at 1-24 months. The stage 1 discovery will involve meta-analysis of individual-level genotypes from different cohorts, controlling for key covariates. Based on statistical significance, supplemented by biological relevance, top single nucleotide polymorphisms will be selected for replication at stage 2. The study has national and local ethical approval. The results of this study will be rapidly communicated to clinicians, researchers and patients through open-access publication(s), presentation(s) at international conferences and via our patient and public network.

Indexed as

Subarachnoid HemorrhageGenome-Wide Association StudyGenotypeHumansMeta-Analysis as TopicPolymorphism, Single NucleotidePrognosisGeneticsHealth careMedicalOutcome assessmentStrokeSubarachnoid haemorrhage

Identifiers

PMID34988871
PMCPMC9232474

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.